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Recombinant human IGFBP7, His-tagged

Cat.No. : IGFBP7-2483H
Product Overview : Recombinant human IGFBP7 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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  • Gene Information
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Description : IGFBP7 is a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm.
Source : E.coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT, 1mM EDTA
Molecular Mass : 28.8kDa (279aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSSSSDTCG PCEPASCPPL PPLGCLLGET RDACGCCPMC ARGEGEPCGG GGAGRGYCAP GMECVKSRKR RKGKAGAAAG GPGVSGVCVC KSRYPVCGSD GTTYPSGCQL RAASQRAESR GEKAITQVSK GTCEQGPSIV TPPKDIWNVT GAQVYLSCEV IGIPTPVLIW NKVKRGHYGV QRTELLPGDR DNLAIQTRGG PEKHEVTGWV LVSPLSKEDA GEYECHASNS QGQASASAKI TVVDALHEIP VKKGEGAEL
Purity : >85 % by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/ml (determined by Bradford assay)
Gene Name : IGFBP7 insulin-like growth factor binding protein 7 [ Homo sapiens ]
Official Symbol : IGFBP7
Synonyms : IGFBP7; insulin-like growth factor binding protein 7; insulin-like growth factor-binding protein 7; FSTL2; IGFBP 7; MAC25; PSF; IGFBP-rP1; angiomodulin; IGF-binding protein 7; PGI2-stimulating factor; tumor-derived adhesion factor; prostacyclin-stimulating factor; AGM; TAF; IBP-7; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1;
Gene ID : 3490
mRNA Refseq : NM_001253835
Protein Refseq : NP_001240764
MIM : 602867
UniProt ID : Q16270
Chromosome Location : 4q12
Pathway : Senescence and Autophagy, organism-specific biosystem;
Function : insulin-like growth factor binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In what types of cancer is IGFBP7 research particularly focused? 07/30/2021

Research on IGFBP7 is often concentrated in breast, lung, prostate, and colorectal cancers, among others.

How does IGFBP7 contribute to cardiovascular health? 12/29/2020

IGFBP7 has been associated with cardiovascular health, and its potential role in protecting against cardiovascular diseases is an area of ongoing research.

Can IGFBP7 be used in therapeutic interventions? 12/04/2020

The potential therapeutic applications of IGFBP7 are being explored, including its use in targeted cancer therapies and other medical interventions.

Can IGFBP7 serve as a biomarker for cancer detection? 09/20/2018

Some studies suggest that IGFBP7 levels in blood or tissues may have potential as a biomarker for cancer detection.

How does IGFBP7 affect cell cycle regulation? 05/11/2018

IGFBP7 has been shown to influence the cell cycle by promoting cell cycle arrest, which can be crucial in preventing uncontrolled cell growth.

Customer Reviews (3)

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Reviews
04/09/2017

    Its purity and stability ensure consistent and accurate results, making it an ideal tool for my research endeavors.

    11/02/2016

      The manufacturer's commitment to maintaining stringent quality control measures guarantees that I can trust the protein's integrity and reliability throughout my experiments.

      09/19/2016

        This partnership enhances research productivity while ensuring accurate and meaningful outcomes.

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