Active Recombinant Human NMNAT1, His-tagged
Cat.No. : | NMNAT1-26H |
Product Overview : | Recombinant Human NMNAT1 fused with N-terminal His-tag, was expressed in an E.coli cell expression system. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 256 mM imidazole and 20% glycerol |
Bio-activity : | 4200 pmol/min/μg Assay Conditions: The 50 μL reaction mixture contained 50 mM Tris-HCl, pH 7.4, 5 mM MgCl2, 0.1 mM NMN, 0.1 mM ATP, and various amounts of NMNAT. |
Molecular Mass : | 32.8 kDa |
AA Sequence : | MHHHHHHENSEKTEVVLLACGSFNP ITNMHLRLFELAKDYMNGTGRYTVV KGIISPVGD AYKKKGLIPAYHRVI MAELATKNSKWVEVDTWESLQKEWK ETLKVLRHHQEKLEASDC DHQQNSPTLERPGRKRKWTETQDSS QKKSLE PKTKAVPKVKLLCGADLLESFAVPN L WKSEDITQIVANYGLICVTRAGNDA QKFIYESDVLWKHRSNIHVVNEW IANDISSTKIRRA LRRGQSIRYLVPDLVQEYIEKHNLY SSESEDRNAGVILAPLQRNTAEAKT |
Purity : | ≥95% |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Stability : | >6 months at –80°C |
Gene Name : | NMNAT1 nicotinamide nucleotide adenylyltransferase 1 [ Homo sapiens (human) ] |
Official Symbol : | NMNAT1 |
Synonyms : | NMNAT1; LCA9; NMNAT; PNAT1; nicotinamide nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1; pyridine nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1; EC 2.7.7.1; EC 2.7.7.18 |
Gene ID : | 64802 |
mRNA Refseq : | NM_022787 |
Protein Refseq : | NP_073624 |
MIM : | 608700 |
UniProt ID : | Q9HAN9 |
Chromosome Location : | 1p36.22 |
Pathway : | Metabolism; Metabolism of vitamins and cofactors; Metabolism of water-soluble vitamins and cofactors |
Function : | ATP binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinamide-nucleotide adenylyltransferase activity |
Products Types
◆ Recombinant Protein | ||
NMNAT1-5937H | Recombinant Human NMNAT1 Protein, GST-tagged | +Inquiry |
Nmnat1-4443M | Recombinant Mouse Nmnat1 Protein, Myc/DDK-tagged | +Inquiry |
NMNAT1-1520H | Recombinant Human NMNAT1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NMNAT1-1163H | Recombinant Human NMNAT1 Protein, MYC/DDK-tagged | +Inquiry |
NMNAT1-77H | Active Recombinant Human NMNAT1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
NMNAT1-001HCL | Recombinant Human NMNAT1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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