Active Human CCL15
Cat.No. : | CCL15-107H |
Product Overview : | It is a synthetic Protein |
- Specification
- Gene Information
- Related Products
Description : | Leukotactin-1 (Lkn-1), also known as Macrophage inflammatory protein 1 delta (MIP-1 ), MIP-5, HCC-2, and NCC-3, is a novel human CC chemokine whose gene was mapped to human chromosome 17 adjacent to the HCC-1 gene. Lkn-1, together with mouse C10, mouse MIP-1 and human MPIF-1, constitute a subgroup of CC chemokines which contain six instead of four conserved cysteine residues. The two additional cysteine residues in Lkn-1 have been shown to form a third disulfide bond. Lkn-1 cDNA encodes a 113 amino acid precursor protein with a putative signal peptide of 21 aa residues that is cleaved to generate a 92 amino acid mature protein. In recombinant Lkn-1 preparations produced in insect cells and in yeast, amino-terminal truncations were found to have occurred. The major forms of Lkn-1 secreted by insect cells and yeast were reported to be proteins of 68 and 66 amino acids, respectively. The full length and the amino-terminal truncated forms of human Lkn-1 have been shown to be potent chemoattractants for monocytes and T-lymphocytes. These proteins can also chemoattract eosinophils and have been shown to induce calcium flux in human CCR-1 transfected cells. Additionally, Lkn-1 can suppress colony formation by human granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors. |
Species : | Human |
Form : | Lyophilized |
Bio-activity : | Activity measured by ability of chemokine to chemoattract THP-1 cells. ED50 for this measurement is generally 2-4 ng/ml. |
Applications : | Activity Assay |
Storage : | Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles |
Reconstitution : | Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly. |
Gene Name : | CCL15 chemokine (C-C motif) ligand 15 [ Homo sapiens ] |
Official Symbol : | CCL15 |
Synonyms : | CCL15; chemokine (C-C motif) ligand 15; SCYA15, small inducible cytokine subfamily A (Cys Cys), member 15; C-C motif chemokine 15; CC chemokine 3; chemokine CC 2; HCC 2; HMRP 2B; leukotactin 1; Lkn 1; macrophage inflammatory protein 5; MIP 1 delta; MIP 1d; MIP 5; NCC 3; SCYL3; MIP-1 delta; chemokine CC-2; new CC chemokine 3; small-inducible cytokine A15; small inducible cytokine subfamily A (Cys-Cys), member 15; LKN1; NCC3; SY15; HCC-2; LKN-1; MIP-5; NCC-3; MIP-1D; MRP-2B; SCYA15; HMRP-2B; |
Gene ID : | 6359 |
mRNA Refseq : | NM_032965 |
Protein Refseq : | NP_116741 |
MIM : | 601393 |
UniProt ID : | Q16663 |
Chromosome Location : | 17q11.2 |
Pathway : | Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | chemoattractant activity; chemokine activity; heparin binding; receptor binding; |
Products Types
◆ Recombinant Protein | ||
CCL15-0611H | Recombinant Human CCL15 Protein, GST-Tagged | +Inquiry |
CCL15-197H | Recombinant Human CCL15 protein(Gln22-Ile113), His-tagged | +Inquiry |
CCL15-070C | Active Recombinant Human CCL15 Protein (92 aa) | +Inquiry |
CCL15-256H | Recombinant Human CCL15 protein(Ser46-Ile113), His-tagged | +Inquiry |
CCL15-326C | Active Recombinant Human CCL15 Protein (92 aa) | +Inquiry |
◆ Lysates | ||
CCL15-7731HCL | Recombinant Human CCL15 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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