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Recombinant Human ADIPOR2, GST-tagged

Cat.No. : ADIPOR2-210H
Product Overview : Human ADIPOR2 full-length ORF ( NP_078827.2, 1 a.a. - 386 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 70.3 kDa
AA Sequence : MNEPTENRLGCSRTPEPDIRLRKGH QLDGTRRGDNDSHQGDLEPILEASV LSSHHKKSSEEHEYSDEAPQEDEGF MGMSPLLQAHHAMEKMEEFVCKVWE GRWRVIPHDVLPDWLKDNDFLLHGH RPPMPSFRACFKSIFRIHTETGNIW THLLGCVFFLCLGIFYMFRPNISFV APLQEKVVFGLFFLGAILCLSFSWL FHTVYCHSEGVSRLFSKLDYSGIAL LIMGSFVPWLYYSFYCNPQPCFIYL IVICVLGIAAIIVSQWDMFATPQYR GVRAGVFLGLGLSGIIPTLHYVISE GFLKAATIGQIGWLMLMASLYITGA ALYAARIPERFFPGKCDIWFHSHQL FHIFVVAGAFVHFHGVSNLQEFRFM IGGGCSEEDAL
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot; Antibody Production; Protein Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ADIPOR2 adiponectin receptor 2 [ Homo sapiens (human) ]
Official Symbol : ADIPOR2
Synonyms : ADIPOR2; PAQR2; ACDCR2; adiponectin receptor 2; progestin and adipoQ receptor family member II
Gene ID : 79602
mRNA Refseq : NM_024551
Protein Refseq : NP_078827
MIM : 607946
UniProt ID : Q86V24
Chromosome Location : 12p13.31
Pathway : AMPK signaling; Adipocytokine signaling pathway
Function : hormone binding; identical protein binding; protein heterodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (12)

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Are there any genetic mutations associated with ADIPOR2? 02/01/2022

Several genetic mutations have been identified in the ADIPOR2 gene that have been linked to obesity and metabolic disorders. However, these mutations are relatively rare and more research is needed to understand their implications for health.

What techniques are used to study ADIPOR2? 04/27/2021

Various techniques are used to study ADIPOR2, including molecular biology techniques such as PCR and Western blotting, imaging techniques such as immunofluorescence and confocal microscopy, and animal models such as knockout mice.

How is ADIPOR2 expression regulated? 10/02/2020

ADIPOR2 expression is regulated by various factors, including adiponectin levels, insulin sensitivity, and inflammation. Certain dietary factors, such as polyphenols and omega-3 fatty acids, have also been shown to increase ADIPOR2 expression.

Does ADIPOR2 play a role in bone health? 09/22/2019

Studies have suggested that ADIPOR2 may have a role in regulating bone metabolism and bone formation. This is because ADIPOR2 activation stimulates osteogenic differentiation and mineralization in bone cells. Therefore, targeting ADIPOR2 activation may be a potential therapeutic strategy for osteoporosis and other bone-related disorders.

How might targeting ADIPOR2 be used in personalized medicine? 06/09/2019

As genetic mutations in the ADIPOR2 gene have been associated with obesity and metabolic disorders, targeting ADIPOR2 could potentially be used in personalized medicine to develop treatments for individuals with specific mutations. However, further research is needed to determine the feasibility and efficacy of this approach.

What are some challenges in developing ADIPOR2-targeted therapies? 10/30/2018

One of the main challenges in developing ADIPOR2-targeted therapies is the potential side effects associated with targeting a receptor that has multiple functions throughout the body. Additionally, more research is needed to fully understand the signaling pathways and mechanisms of ADIPOR2 activation, which could impact the development of effective and safe therapies.

Can ADIPOR2 activation be used as a therapeutic target for cardiovascular diseases? 09/01/2018

Yes, ADIPOR2 activation has been shown to have beneficial effects on cardiovascular health. This includes improving vascular function, reducing oxidative stress, and decreasing inflammation. Therefore, targeting ADIPOR2 activation may be a viable therapeutic strategy for cardiovascular diseases such as atherosclerosis and hypertension.

What role does ADIPOR2 play in insulin resistance? 10/12/2017

ADIPOR2 has been suggested to play a role in insulin resistance by regulating glucose uptake and lipid oxidation. In insulin-resistant individuals, ADIPOR2 expression and activation may be reduced, leading to impaired glucose uptake and metabolism. Therefore, targeting ADIPOR2 activation may be beneficial in improving insulin sensitivity.

Is ADIPOR2 associated with cancer? 10/03/2017

There is some evidence to suggest that ADIPOR2 may play a role in cancer development and progression. Studies have found that ADIPOR2 expression is reduced in certain types of cancer, but more research is needed to fully understand its implications for cancer.

Can ADIPOR2 be used as a therapeutic target for metabolic disorders? 08/16/2017

There is growing interest in ADIPOR2 as a potential therapeutic target for metabolic disorders such as obesity and type 2 diabetes. However, more research is needed to fully understand the mechanisms of ADIPOR2 and its potential as a drug target.

What are the potential side effects of targeting ADIPOR2 for therapy? 11/01/2016

As ADIPOR2 has various functions throughout the body, targeting it for therapy may have potential side effects. These could include changes in glucose and lipid metabolism, as well as effects on the central nervous system.

Is there a link between ADIPOR2 and neurodegenerative diseases? 04/08/2016

Recent studies have suggested a potential link between ADIPOR2 and neurodegenerative diseases such as Alzheimer's and Parkinson's disease. This is because ADIPOR2 activation may have a protective effect on neurons by reducing oxidative stress and inflammation. However, more research is needed to fully understand the role of ADIPOR2 in neurodegenerative diseases.

Customer Reviews (5)

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Reviews
05/18/2022

    ADIPOR2 protein and manufacturer's support have been instrumental in my research progress, and I highly recommend their products to fellow researchers.

    08/03/2020

      I am pleased to report that the ADIPOR2 protein provided by the manufacturer is of exceptional quality and perfectly meets the needs of my ongoing experiments.

      01/20/2020

        the excellent technical support and customer service provided by the manufacturer have been very helpful in resolving any issues I encountered during the experimental process.

        11/20/2016

          The combination of high-quality protein, expert technical support, and commitment to scientific excellence has made them an invaluable partner in my research endeavors.

          03/19/2016

            The purity and consistency of the ADIPOR2 protein are evident in the reproducible results I have obtained in my experiments.

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