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Recombinant Human PTPN2, Gly & Pro tagged

Cat.No. : PTPN2-470H
Product Overview : Recombinant Human PTPN2 (P17706-1) (Met1-Asn314), fused with two additional amino acids (Gly & Pro) at the N-terminus, was produced in Baculovirus-Insect cells.
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  • Gene Information
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Source : Baculovirus-Insect cells
Species : Human
Tag : Gly & Pro
Predicted N Terminal : Gly
Form : Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The secreted recombinant human PTPN2 consists of 316 amino acids and predicts a molecular mass of 36.8 KDa. The apparent molecular mass of the protein is approximately 37 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >95 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : PTPN2 protein tyrosine phosphatase, non-receptor type 2 [ Homo sapiens ]
Official Symbol : PTPN2
Gene ID : 5771
mRNA Refseq : NM_001207013
Protein Refseq : NP_001193942
MIM : 176887
UniProt ID : P17706
Chromosome Location : 18p11.3-p11.2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the therapeutic effect of specific PTPN2 inhibitors on inflammatory diseases? 09/30/2022

PTPN2 inhibitors can inhibit certain signaling pathways in the inflammatory response, thereby playing a role in the treatment of inflammatory diseases.

Is there a soluble PTPN2 protein? 01/06/2022

Yes, soluble PTPN2 proteins exist that can be detected in extracellular fluids and may play a role in regulating cell-to-cell communication and signal transduction.

What is the modulating effect of soluble PTPN2 protein on immune response? 03/17/2021

PTPN2 protein can interact with receptors on the surface of immune cells to regulate the activation and function of immune cells, thereby playing a role in regulating immune responses.

What is the role of PTPN2 protein in autoimmune diseases? 01/15/2021

Studies have shown that PTPN2 protein plays a certain role in autoimmune diseases, and its expression level may be related to the occurrence and progression of the disease.

Are specific PTPN2 inhibitors useful for the treatment of autoimmune diseases? 11/02/2020

Specific PTPN2 inhibitors can inhibit certain abnormal signaling pathways in autoimmune diseases, thereby playing a role in the treatment of autoimmune diseases.

How does PTPN2 protein regulate immune response? 04/16/2020

This protein can interact with a variety of immune molecules, such as T cell receptors (TCRs) and B cell receptors (BCRs), to regulate immune responses by regulating their phosphorylation status.

Customer Reviews (3)

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Reviews
10/06/2022

    Repeatability is good, and the results of multiple experiments are consistent.

    08/10/2022

      The impurities are very well removed and the purity is very high.

      04/14/2021

        Performance is very stable and the price is very reasonable. I would definitely buy this product again.

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