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Recombinant Human LILRB2, His-tagged

Cat.No. : LILRB2-115H
Product Overview : Recombinant Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2/LILRB2 produced by transfected human cells is a secreted protein with sequence (Gln22-His458) of Human LILRB2 fused with a polyhistidine tag at the C-terminus.
  • Specification
  • Gene Information
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Description : Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.2
AA Sequence : QTGTIPKPTLWAEPDSVITQGSPVT LSCQGSLEAQEYRLYREKKSASWIT RIRPELVKNGQFHIP SITWEHTGRYGCQYYSRARWSELSD PLVLVMTGAYPKPTLSAQPSPVVTS GGRVTLQCESQVAFG GFILCKEGEDEHPQCLNSQPHARGS SRAIFSVGPVSPNRRWSHRCYGYDL NSPYVWSSPSDLLEL LVPGVSKKPSLSVQPGPVVAPGESL TLQCVSDVGYDRFVLYKEGERDLRQ LPGRQPQAGLSQANF TLGPVSRSYGGQYRCYGAYNLSSEW SAPSDPLDILITGQIHGTPFISVQP GPTVASGENVTLLCQ SWRQFHTFLLTKAGAADAPLRLRSI HEYPKYQAEFPMSPVTSAHAGTYRC YGSLNSDPYLLSHPS EPLELVVSGPSMGSSPPPTGPISTP AGPEDQPLTPTGSDPQSGLGRHVDH HHHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Storage : Lyophilized protein should be stored at Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 [ Homo sapiens ]
Official Symbol : LILRB2
Synonyms : LILRB2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; leukocyte immunoglobulin-like receptor subfamily B member 2; CD85d; ILT4; LIR 2; LIR2; MIR 10; MIR10; ILT-4; Ig-like transcript 4; immunoglobulin-like transcript 4; CD85 antigen-like family member D; leukocyte immunoglobulin-like receptor 2; monocyte/macrophage immunoglobulin-like receptor 10; leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform; eukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6; CD85D; LIR-2; LILRA6; MIR-10;
Gene ID : 10288
mRNA Refseq : NM_001080978
Protein Refseq : NP_001074447
MIM : 604815
UniProt ID : Q8N423
Chromosome Location : 19q13.4
Pathway : Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem;
Function : MHC class I protein binding; MHC class I protein binding; MHC class Ib protein binding; cell adhesion molecule binding; eukaryotic cell surface binding; inhibitory MHC class I receptor activity; inhibitory MHC class I receptor activity; protein binding; protein phosphatase 1 binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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