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Recombinant Human KLK2, His-tagged

Cat.No. : KLK2-122H
Product Overview : Recombinant Human Kallikrein 2/KLK2 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Pro19-Pro261) of Human KLK2 fused with a polyhistidine tag at the C-terminus.
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Description : Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.
Source : HEK293
Species : Human
Tag : His
Form : Supplied as a 0.2 μM filtered solution of 20mM Citrate, 150mM NaCl, pH 3.5
AA Sequence : PLIQSRIVGGWECEKHSQPWQVAVY SHGWAHCGGVLVHPQWVLTAAHCLK KNSQVWLGRHNLFEP EDTGQRVPVSHSFPHPLYNMSLLKH QSLRPDEDSSHDLMLLRLSEPAKIT DVVKVLGLPTQEPAL GTTCYASGWGSIEPEEFLRPRSLQC VSLHLLSNDMCARAYSEKVTEFMLC AGLWTGGKDTCGGDS GGPLVCNGVLQGITSWGPEPCALPE KPAVYTKVVHYRKWIKDTIAANPVD HHHHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Storage : Store at Please minimize freeze-thaw cycles.
Gene Name : KLK2 kallikrein-related peptidase 2 [ Homo sapiens ]
Official Symbol : KLK2
Synonyms : KLK2; kallikrein-related peptidase 2; kallikrein 2, prostatic; kallikrein-2; tissue kallikrein-2; glandular kallikrein 2; glandular kallikrein-1; hK2; hGK-1; KLK2A2; FLJ17010; FLJ17011; MGC12201;
Gene ID : 3817
mRNA Refseq : NM_001002231
Protein Refseq : NP_001002231
MIM : 147960
UniProt ID : P20151
Chromosome Location : 19q13.33
Pathway : Activation of Matrix Metalloproteinases, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; Extracellular matrix organization, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem;
Function : peptidase activity; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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