Recombinant Human OTX2
Cat.No. : | OTX2-165H |
Product Overview : | Recombinant Human Homeobox Protein OTX2 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Leu297) of Human OTX2. |
- Specification
- Gene Information
- Related Products
Description : | Homeobox Protein OTX2 is a number of the paired homeobox family of the Bicoid subfamily. OTX2 contains 1 homeobox DNA-binding domain and expresses in brain. OTX2 may play a role in the development of the brain and the sense organs. OTX2 positively regulate of gastrulation and embryonic development. Defects in OTX2 are the cause of microphthalmia syndromic type 5, which is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. It also causes pituitary hormone deficiency combined type 6. Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.4 |
AA Sequence : | MMSYLKQPPYAVNGLSLTTSGMDLL HPSVGYPGPWASCPAATPRKQRRER TTFTRAQLDVLEALF AKTRYPDIFMREEVALKINLPESRV QVWFKNRRAKCRQQQQQQQNGGQNK VRPAKKKTSPAREVS SESGTSGQFTPPSSTSVPTIASSSA PVSIWSPASISPLSDPLSTSSSCMQ RSYPMTYTQASGYSQ GYAGSTSYFGGMDCGSYLTPMHHQL PGPGATLSPMGTNAVTSHLNQSPAS LSTQGYGASSLGFNS TTDCLDYKDQTASWKLNFNADCLDY KDQTSSWKFQVLLEHHHHHH |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | OTX2 orthodenticle homeobox 2 [ Homo sapiens ] |
Official Symbol : | OTX2 |
Synonyms : | OTX2; orthodenticle homeobox 2; orthodenticle homolog 2 (Drosophila); homeobox protein OTX2; orthodenticle homolog 2; CPHD6; MCOPS5; MGC45000; |
Gene ID : | 5015 |
mRNA Refseq : | NM_021728 |
Protein Refseq : | NP_068374 |
MIM : | 600037 |
UniProt ID : | P32243 |
Chromosome Location : | 14q22.3 |
Function : | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; eukaryotic initiation factor 4E binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; |
Products Types
◆ Recombinant Protein | ||
OTX2-26H | Recombinant Human OTX2 Protein, His-tagged | +Inquiry |
OTX2-4776H | Recombinant Human OTX2 Protein (Met1-Leu297), C-His tagged | +Inquiry |
OTX2-390H | Recombinant Human OTX2 Protein, His-tagged | +Inquiry |
OTX2-193H | Recombinant Human OTX2 protein, T7/His-tagged | +Inquiry |
OTX2-6089C | Recombinant Chicken OTX2 | +Inquiry |
◆ Lysates | ||
OTX2-3511HCL | Recombinant Human OTX2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionAs of my last knowledge update, there were no specific drugs targeting OTX2 in advanced stages of development, but ongoing research might uncover potential drug candidates.
Yes, gene therapy targeting the OTX2 gene is being investigated as a potential approach for treating disorders related to OTX2 dysfunction.
While not yet widely used in clinical practice, diagnostic tests assessing OTX2 expression levels may become relevant in the future for certain developmental and neurological disorders.
OTX2 has been implicated in certain types of brain tumors, and understanding its role in cancer may provide insights into potential targeted therapies.
As of my last knowledge update in January 2022, specific clinical trials involving OTX2 were not widely reported. However, ongoing research may have progressed since then.
Customer Reviews (3)
Write a reviewThe OTX2 protein is of exceptional quality, meeting all my experimental requirements with precision and reliability.
This dedication ensures that I have access to the most advanced and reliable protein in my studies, enhancing the overall quality and impact of my research outcomes.
This exceptional level of support enables me to overcome challenges efficiently and progress smoothly with my research.
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