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Recombinant Human OTX2

Cat.No. : OTX2-165H
Product Overview : Recombinant Human Homeobox Protein OTX2 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Leu297) of Human OTX2.
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Description : Homeobox Protein OTX2 is a number of the paired homeobox family of the Bicoid subfamily. OTX2 contains 1 homeobox DNA-binding domain and expresses in brain. OTX2 may play a role in the development of the brain and the sense organs. OTX2 positively regulate of gastrulation and embryonic development. Defects in OTX2 are the cause of microphthalmia syndromic type 5, which is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. It also causes pituitary hormone deficiency combined type 6. Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.4
AA Sequence : MMSYLKQPPYAVNGLSLTTSGMDLL HPSVGYPGPWASCPAATPRKQRRER TTFTRAQLDVLEALF AKTRYPDIFMREEVALKINLPESRV QVWFKNRRAKCRQQQQQQQNGGQNK VRPAKKKTSPAREVS SESGTSGQFTPPSSTSVPTIASSSA PVSIWSPASISPLSDPLSTSSSCMQ RSYPMTYTQASGYSQ GYAGSTSYFGGMDCGSYLTPMHHQL PGPGATLSPMGTNAVTSHLNQSPAS LSTQGYGASSLGFNS TTDCLDYKDQTASWKLNFNADCLDY KDQTSSWKFQVLLEHHHHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Storage : Lyophilized protein should be stored at Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : OTX2 orthodenticle homeobox 2 [ Homo sapiens ]
Official Symbol : OTX2
Synonyms : OTX2; orthodenticle homeobox 2; orthodenticle homolog 2 (Drosophila); homeobox protein OTX2; orthodenticle homolog 2; CPHD6; MCOPS5; MGC45000;
Gene ID : 5015
mRNA Refseq : NM_021728
Protein Refseq : NP_068374
MIM : 600037
UniProt ID : P32243
Chromosome Location : 14q22.3
Function : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; eukaryotic initiation factor 4E binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific drugs targeting OTX2 currently in development? 09/15/2022

As of my last knowledge update, there were no specific drugs targeting OTX2 in advanced stages of development, but ongoing research might uncover potential drug candidates.

Can OTX2 be a target for gene therapy? 09/29/2020

Yes, gene therapy targeting the OTX2 gene is being investigated as a potential approach for treating disorders related to OTX2 dysfunction.

Can alterations in OTX2 expression be detected through diagnostic tests? 05/13/2017

While not yet widely used in clinical practice, diagnostic tests assessing OTX2 expression levels may become relevant in the future for certain developmental and neurological disorders.

How is OTX2 relevant to cancer research? 12/26/2016

OTX2 has been implicated in certain types of brain tumors, and understanding its role in cancer may provide insights into potential targeted therapies.

Are there any ongoing clinical trials involving OTX2? 12/20/2016

As of my last knowledge update in January 2022, specific clinical trials involving OTX2 were not widely reported. However, ongoing research may have progressed since then.

Customer Reviews (3)

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Reviews
02/18/2023

    The OTX2 protein is of exceptional quality, meeting all my experimental requirements with precision and reliability.

    06/05/2020

      This dedication ensures that I have access to the most advanced and reliable protein in my studies, enhancing the overall quality and impact of my research outcomes.

      06/11/2018

        This exceptional level of support enables me to overcome challenges efficiently and progress smoothly with my research.

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