Recombinant Human SIAE, His-tagged
Cat.No. : | SIAE-189H |
Product Overview : | Recombinant Human Sialate O-Acetylesterase/SIAE is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ile24-Lys523) of Human SIAE fused with a 6His tag at the C-terminus. |
- Specification
- Gene Information
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Description : | Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis, prostate, and colon. SIAE catalyzes N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
AA Sequence : | IGFRFASYINNDMVLQKEPAGAVIW GFGTPGATVTVTLRQGQETIMKKVT SVKAHSDTWMVVLDP MKPGGPFEVMAQQTLEKINFTLRVH DVLFGDVWLCSGQSNMQMTVLQIFN ATRELSNTAAYQSVR ILSVSPIQAEQELEDLVAVDLQWSK PTSENLGHGYFKYMSAVCWLFGRHL YDTLQYPIGLIASSW GGTPIEAWSSGRSLKACGVPKQGSI PYDSVTGPSKHSVLWNAMIHPLCNM TLKGVVWYQGESNIN YNTDLYNCTFPALIEDWRETFHRGS QGQTERFFPFGLVQLSSDLSKKSSD DGFPQIRWHQTADFG YVPNPKMPNTFMAVAMDLCDRDSPF GSIHPRDKQTVAYRLHLGARALAYG EKNLTFEGPLPEKIE LLAHKGLLNLTYYQQIQVQKKDNKI FEISCCSDHRCKWLPASMNTVSTQS LTLAIDSCHGTVVAL RYAWTTWPCEYKQCPLYHPSSALPA PPFIAFITDQGPGHQSNVAKVDHHH HHH |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Gene Name : | SIAE sialic acid acetylesterase [ Homo sapiens ] |
Official Symbol : | SIAE |
Synonyms : | SIAE; sialic acid acetylesterase; YSG2, Ysg2 homolog (mouse); sialate O-acetylesterase; CSE C; LSE; MGC87009; sialic acid specific acetylesterase II; H-Lse; sialic acid-specific acetylesterase II; cytosolic sialic acid 9-O-acetylesterase homolog; AIS6; CSEC; YSG2; CSE-C; |
Gene ID : | 54414 |
mRNA Refseq : | NM_001199922 |
Protein Refseq : | NP_001186851 |
MIM : | 610079 |
UniProt ID : | Q9HAT2 |
Chromosome Location : | 11q24 |
Function : | carboxylesterase activity; hydrolase activity; sialate O-acetylesterase activity; |
Products Types
◆ Recombinant Protein | ||
Siae-5873M | Recombinant Mouse Siae Protein, Myc/DDK-tagged | +Inquiry |
SIAE-694H | Recombinant Human SIAE Protein, His/GST-tagged | +Inquiry |
SIAE-8167M | Recombinant Mouse SIAE Protein, His (Fc)-Avi-tagged | +Inquiry |
SIAE-4015R | Recombinant Rhesus Macaque SIAE Protein, His (Fc)-Avi-tagged | +Inquiry |
SIAE-2007H | Recombinant Human SIAE Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SIAE-001HCL | Recombinant Human SIAE cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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