| Description : |
Interleukin-17F (IL17F) also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). |
| Source : |
HEK293 |
| Species : |
Human |
| Predicted N Terminal : |
Arg 31 |
| Form : |
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization. |
| Bio-activity : |
The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts. The ED50 for this effect is typically 100 to 500 ng/ml. |
| Molecular Mass : |
rhIL17F, contains no "tag", has a calculated MW of 15.5 kDa. DTT-reduced Protein migrates as 21 kDa due to glycosylation. |
| Endotoxin : |
Less than 1.0 EU per μg of the rhIL17F by the LAL method. |
| Purity : |
>95% as determined by SDS-PAGE. |
| Storage : |
Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In?lyophilized state?for?1 year?(4 centigrade-8 centigrade); Afterreconstitution?under sterile conditions for?1 month?(4 centigrade-8 centigrade) or?3 months?(-20 centigrade to -70 centigrade). |
