Recombinant Human CCR5, GST-tagged
Cat.No. : | CCR5-120H |
Product Overview : | CCR5 (XP_001125981.1, 1 a.a. - 352 a.a.) recombinant protein with a ~26kD N-terminal GST tag.. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 66.9 kDa |
AA Sequence : | MDYQVSSPIYDINYYTSEPCQKINV KQIAARLLPPLYSLVFIFGFVGNML VILILINCKRLKSMTDIYLLNLAIS DLFFLLTVPFWAHYAAAQWDFGNTM CQLLTGLYFIGFFSGIF FIILLTIDRYLAVVHAVFALKARTV TFGVVTS VITWVVAVFASLPGIIFTRSQKEGL HYTCSSHFPYSQYQFWKNFQTLKIV ILGLVLPLLVMVICYSGILKTLLRC RNEKKRHRAV RLIFTIMIVYFLFWAPYNIVLLLNT FQEFFGLNNCSSSNRLDQAMQVTET LGMTHCCINPIIYA FVGEKFRNYLLVFFQKHIAKRFCKC CSIFQQEAPERASSVYTRSTGEQEI SVGL |
Applications : | Western Blot; ELISA; Protein Array; Antibody Production |
Storage : | Store at -80C. Avoid freeze-thaw cycles. |
Gene Name : | CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) [ Homo sapiens (human) ] |
Official Symbol : | CCR5 |
Synonyms : | CCR5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; chemokine (C-C motif) receptor 5 (gene/pseudogene); C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A |
Gene ID : | 1234 |
mRNA Refseq : | NM_000579 |
Protein Refseq : | NP_000570 |
MIM : | 601373 |
UniProt ID : | P51681 |
Chromosome Location : | 3p21.31 |
Pathway : | Binding and entry of HIV virion; Chemokine receptors bind chemokines; Class A/1 (Rhodopsin-like receptors) |
Function : | C-C chemokine binding; chemokine (C-C motif) ligand 5 binding; phosphatidylinositol phospholipase C activity |
Products Types
◆ Recombinant Protein | ||
CCR5-192H | Recombinant Human CCR5 Protein, His-tagged | +Inquiry |
CCR5-887R | Recombinant Rat CCR5 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCR5-535R | Recombinant Rhesus Macaque CCR5 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCR5-1423M | Recombinant Mouse CCR5 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCR5-0693H | Recombinant Human CCR5 Protein | +Inquiry |
◆ Lysates | ||
CCR5-309HCL | Recombinant Human CCR5 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1154 | CCR5 Activated GPCR Internalization Assay Kit | +Inquiry |
Kit-1155 | cAMP CCR5 CHO-K1 GPCR Assay Kit | +Inquiry |
Kit-1153 | CCR5 CHO-K1 β-Arrestin GPCR Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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