Active Recombinant Human IFNB1
Cat.No. : | IFNB1-533H |
Product Overview : | Recombinant Human IFNB1 produced in E. coli is approximately 20.0 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids. |
- Specification
- Gene Information
- Related Products
Description : | IFN-βs are proteins produced by many cell types including lymphocytes (NK cells, B-cells and T-cells), macrophages, fibroblasts, endothelial cells, osteoblasts and others. They have antiviral activity that it is mainly involved in innate immune response. The IFN-β family has 2 subtypes,which are IFN-β1 (IFNB1) and IFN-β3 (IFNB3) (a gene designated IFN-β2 is actually IL-6). IFN-β1 is used as a treatment for multiple sclerosis as it reduces the relapse rate. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, containing 2% HSA and 3% mannitol. |
Bio-activity : | Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 3.2 × 10^7IU/mg. |
Molecular Mass : | 20 kDa |
AA Sequence : | MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN |
Endotoxin : | Less than 1EU/μg of rHuIFN-β1b as determined by LAL method. |
Purity : | >97% by SDS-PAGE and HPLC analyses. |
Usage : | This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. |
Storage : | This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles. |
Reconstitution : | We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ] |
Official Symbol : | IFNB1 |
Synonyms : | IFNB1; interferon, beta 1, fibroblast; IFNB; interferon beta; IFB; IFF; IFN-beta; fibroblast interferon; MGC96956; |
Gene ID : | 3456 |
mRNA Refseq : | NM_002176 |
Protein Refseq : | NP_002167 |
MIM : | 147640 |
UniProt ID : | P01574 |
Chromosome Location : | 9p22 |
Pathway : | Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; |
Function : | cytokine activity; interferon-alpha/beta receptor binding; transcription corepressor activity; |
Products Types
◆ Recombinant Protein | ||
Ifnb1-10566M | Recombinant Mouse Ifnb1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IFNB1-4405R | Recombinant Rabbit IFNB1 Protein | +Inquiry |
IFNB1-2271P | Recombinant Pig IFNB1 Protein, His-tagged | +Inquiry |
IFNB1-496M | Recombinant Mouse IFNB1 Protein | +Inquiry |
Ifnb1-117M | Recombinant Active Mouse IFNB1 Protein, His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
IFNB1-889CCL | Recombinant Cynomolgus IFNB1 cell lysate | +Inquiry |
IFNB1-2931HCL | Recombinant Human IFNB1 cell lysate | +Inquiry |
IFNB1-001HCL | Recombinant Human IFNB1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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