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Recombinant Human RB1

Cat.No. : RB1-651H
Product Overview : Recombinant Human RB1 produced in E. coli is approximately 16.5 kDa, a single non-glycosylated polypeptide chain containing 146 amino acids.
  • Specification
  • Gene Information
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Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Molecular Mass : 16.5 kDa
AA Sequence : MASFPSSPLR IPGGNIYISP LKSPYKISEG LPTPTKMTPR SRILVSIGES FGTSEKFQKI NQMVCNSDRV LKRSAEGSNP PKPLKKLRFD IEGSDEADGS KHLPGESKFQ QKLAEMTSTR TRMQKQKMND SMDTSNKEEK HHHHHH
Endotoxin : Less than 1 EU/μg of rHuRb137 as determined by LAL method.
Purity : >95% by SDS-PAGE and HPLC analyses.
Usage : This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage : This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution : We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at< -20 centigrade. further dilutions should be made in appropriate buffered solutions.>
Gene Name : RB1 retinoblastoma 1 [ Homo sapiens ]
Official Symbol : RB1
Synonyms : RB1; retinoblastoma 1; OSRC, osteosarcoma; retinoblastoma-associated protein; RB; retinoblastoma suspectibility protein; pRb; OSRC; pp110; p105-Rb;
Gene ID : 5925
mRNA Refseq : NM_000321
Protein Refseq : NP_000312
MIM : 614041
UniProt ID : P06400
Chromosome Location : 13q14.2
Pathway : Adipogenesis, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem;
Function : DNA binding; RNA polymerase II activating transcription factor binding; androgen receptor binding; core promoter binding; kinase activity; kinase binding; molecular_function; phosphoprotein binding; protein binding; sequence-specific DNA binding transcrip

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of RB1 mutations on the development of retinoblastoma and other cancers? 02/14/2022

Mutations in RB1 lead to retinoblastoma and increase the risk of other cancers, disrupting normal cell cycle control.

How does RB1 interact with transcription factors and affect gene expression? 10/30/2021

RB1 interacts with transcription factors to regulate gene expression, impacting various cellular processes.

What role does RB1 play in DNA damage response and repair mechanisms? 02/25/2021

RB1 plays a crucial role in the DNA damage response, facilitating repair and maintaining genomic stability.

How does RB1 regulate the cell cycle, particularly the transition from G1 to S phase? 04/09/2020

RB1 controls the G1 to S phase transition in the cell cycle, preventing unregulated cell division.

How do alterations in RB1 expression or function influence stem cell differentiation and tissue regeneration? 10/25/2019

Changes in RB1 function affect stem cell differentiation and tissue regeneration, influencing tissue maintenance and repair.

What are the mechanisms by which RB1 modulates cellular senescence and apoptosis? 09/03/2019

RB1 influences cellular senescence and apoptosis, playing a role in aging and cell turnover.

How does RB1 contribute to tumor suppression and the prevention of uncontrolled cell proliferation? 02/17/2019

As a tumor suppressor, RB1 prevents excessive cell proliferation and contributes to cancer prevention.

Customer Reviews (3)

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Reviews
07/15/2022

    Efficient protein purification, delivers consistent yield and purity.

    01/19/2021

      Expertise in protein engineering, a trusted resource for research.

      10/09/2019

        Reliable protein crystallization services, exceptional results achieved.

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