Active Recombinant Human CDK2/CyclinO, GST-tagged
Cat.No. : | CDK2-114H |
Product Overview : | Recombinant full-length human CDK2/Cyclin O was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | CDK2/CyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/CyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | The specific activity of CDK2/CyclinO was determined to be 46.0 nmol /min/mg |
Molecular Mass : | CDK2 ~58 kDa and Cyclin O ~68 kDa |
Purity : | >90% by densitometry |
Applications : | Kinase Assay, Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | CDK2 cyclin-dependent kinase 2 [ Homo sapiens ] |
Official Symbol : | CDK2 |
Synonyms : | CDK2; cyclin-dependent kinase 2; p33 protein kinase; cell devision kinase 2; cdc2-related protein kinase; cell division protein kinase 2; p33(CDK2); |
Gene ID : | 1017 |
mRNA Refseq : | NM_001798 |
Protein Refseq : | NP_001789 |
MIM : | 116953 |
UniProt ID : | P24941 |
Chromosome Location : | 12q13 |
Pathway : | APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; CDK-mediated phosphorylation and removal of Cdc6, organism-specific biosystem; Cell Cycle, organism-specific biosystem; |
Function : | ATP binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase activity; contributes_to histone kinase activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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