Recombinant Human PTK7, GST-tagged

• Cat.No.: PTK7-183H
• Product Overview: Recombinant human PTK7 (726-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: PTK7 or pseudo protein tyrosine kinase 7 is a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. PTK7 lacks detectable catalytic tyrosine kinase activity but is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. PTK7 interacts with β-catenin and functions upstream from glycogen synthase kinase 3. PTK7 has been isolated from colon carcinoma and was designated colon carcinoma kinase-4. In conjunction with other T cell markers, PTK7 has utility as a biomarker for detecting minimal residual disease of T-ALL in the bone marrow.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~66 kDa
• Purity: >95% by densitometry
• Applications: Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: PTK7 PTK7 protein tyrosine kinase 7 [ Homo sapiens ]
• Official Symbol: PTK7
• Synonyms: PTK7; PTK7 protein tyrosine kinase 7; inactive tyrosine-protein kinase 7; CCK4; CCK-4; colon carcinoma kinase 4; colon carcinoma kinase-4; protein-tyrosine kinase 7; tyrosine-protein kinase-like 7; pseudo tyrosine kinase receptor 7
• Gene ID: 5754
• mRNA Refseq: NM_002821
• Protein Refseq: NP_002812
• MIM: 601890
• UniProt ID: Q13308
• Chromosome Location: 6p21.1-p12.2
• Function: ATP binding; receptor activity; transferase activity, transferring phosphorus-containing groups; transmembrane receptor protein tyrosine kinase activity