Active Recombinant Human CREBBP, GST-tagged
Cat.No. : | CREBBP-192H |
Product Overview : | Recombinant human KAT3A (CREBBP) (1319-1710) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | KAT3A has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. KAT3A (CREBBP) expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. KAT3A plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. KAT3A also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | The specific activity of KAT3A (CREBBP) was determined to be 32 nmol /min/mg |
Molecular Mass : | ~72 kDa |
Purity : | >90% by densitometry |
Applications : | Acetyltransferase Assay |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | CREBBP CREB binding protein [ Homo sapiens ] |
Official Symbol : | CREBBP |
Synonyms : | CREBBP; CREB binding protein; RSTS, Rubinstein Taybi syndrome; CREB-binding protein; CBP; KAT3A; RTS; RSTS; |
Gene ID : | 1387 |
mRNA Refseq : | NM_001079846 |
Protein Refseq : | NP_001073315 |
MIM : | 600140 |
UniProt ID : | Q92793 |
Chromosome Location : | 16p13.3 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Angiogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Cell cycle, organism-specific biosystem; |
Function : | DNA binding; MyoD binding; RNA polymerase II activating transcription factor binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II transcription coactivator activity; RNA polymerase II transcription factor binding; RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; SMAD binding; acetyltransferase activity; chromatin binding; core promoter proximal region sequence-specific DNA binding; histone acetyltransferase activity; histone acetyltransferase activity; metal ion binding; p53 binding; peroxisome proliferator activated receptor binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; transcription coactivator activity; contributes_to transcription coactivator activity; transcription coactivator activity; transcription coactivator activity; transcription factor binding; transferase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
CREBBP-001H | Recombinant Human CREBBP Protein, GST-tagged | +Inquiry |
CREBBP-01D | Recombinant Dog Crebbp Protein, His tagged | +Inquiry |
CREBBP-1852H | Recombinant Human CREBBP Protein, GST-tagged | +Inquiry |
CREBBP-22HCL | Recombinant Human CREBBP 293 Cell Lysate | +Inquiry |
CREBBP-847R | Recombinant Rhesus Macaque CREBBP Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1710 | CREBBP Inhibitor Screening Assay Kit | +Inquiry |
Kit-1711 | CREBBP TR-FRET Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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