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Recombinant Human BRPF3, GST-tagged

Cat.No. : BRPF3-160H
Product Overview : Recombinant Human BRPF3 bromodomain (576-701 aa) fused to a GST tag at the N-terminus
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  • Gene Information
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Description : The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. Bromodomain and PHD finger containing 3 (BRPF3) is a component of the MOZ/MORF histone acetyltransferase (HAT) complex. The addition of BRPF proteins to MOZ/MORF increases its HAT activity.3 Consequently, BRPF3 is likely to play a role in regulation of transcriptional activation by MOZ/MORF. This product contains the first bromodomain of BRPF3.
Source : E. coli
Species : Human
Tag : GST
Form : Liquid. 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
Molecular Mass : 41.2 kDa (576-701 aa + NT GST Tag)
Purity : ≥95%
Storage : Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year.
Gene Name : BRPF3 bromodomain and PHD finger containing, 3 [ Homo sapiens ]
Official Symbol : BRPF3
Synonyms : BRPF3; bromodomain and PHD finger containing, 3; bromodomain and PHD finger-containing protein 3; KIAA1286;
Gene ID : 27154
mRNA Refseq : NM_015695
Protein Refseq : NP_056510
UniProt ID : Q9ULD4
Chromosome Location : 6p21.31
Pathway : Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem; Response to elevated platelet cytosolic Ca2+, organism-specific biosystem;
Function : metal ion binding; protein binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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