Recombinant Human TAF1, GST-tagged
Cat.No. : | TAF1-165H |
Product Overview : | Recombinant Human TAF1 bromodomain 1 (1371-1496 aa) fused to a GST tag at the N-terminus |
- Specification
- Gene Information
- Related Products
Description : | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | Liquid. 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol. |
Molecular Mass : | 41.7 kDa (1371-1496 aa + NT GST Tag) |
Purity : | ≥95% |
Storage : | Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year. |
Gene Name : | TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa [ Homo sapiens ] |
Official Symbol : | TAF1 |
Synonyms : | TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; BA2R, CCG1, CCGS, dystonia 3 (with Parkinsonism) , DYT3, TAF2A, TATA box binding protein (TBP) associated factor, RNA polymerase II, A, 250kD; transcription initiation factor TFIID subunit 1; DYT3/TAF1; KAT4; NSCL2; TAFII250; TAFII-250; TAF(II)250; cell cycle gene 1 protein; cell cycle, G1 phase defect; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; complementation of cell cycle block, G1-to-S; transcription initiation factor TFIID 250 kDa subunit; OF; XDP; BA2R; CCG1; CCGS; DYT3; P250; TAF2A; N-TAF1; |
Gene ID : | 6872 |
mRNA Refseq : | NM_004606 |
Protein Refseq : | NP_004597 |
MIM : | 313650 |
UniProt ID : | P21675 |
Chromosome Location : | Xq13.1 |
Pathway : | Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Disease, organism-specific biosystem; Gene Expression, organism-specific biosystem; HIV Infection, organism-specific biosystem; HIV Life Cycle, organism-specific biosystem; HIV-1 Transcription Initiation, organism-specific biosystem; |
Function : | ATP binding; TBP-class protein binding; histone acetyl-lysine binding; histone acetyltransferase activity; kinase activity; nucleotide binding; p53 binding; protein binding; protein serine/threonine kinase activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; contributes_to transcription regulatory region DNA binding; transferase activity; |
Products Types
◆ Recombinant Protein | ||
TAF1-216H | Recombinant Human TAF1 Protein, His-tagged | +Inquiry |
TAF1-213H | Recombinant Human TAF1 Protein, GST-tagged | +Inquiry |
TAF1-3927Z | Recombinant Zebrafish TAF1 | +Inquiry |
TAF1-122H | Recombinant Human TAF1, GST-tagged | +Inquiry |
TAF1-214H | Recombinant Human TAF1 Protein, His-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1873 | TAF1 (BD1/BD2) Inhibitor Screening Assay Kit | +Inquiry |
Kit-2033 | TAF1 bromodomains 1 and 2 TR-FRET Assay Kit | +Inquiry |
Kit-2032 | TAF1 bromodomain 1 TR-FRET Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTAF1 specifically modulates the expression of certain genes, impacting diverse cellular functions and processes.
TAF1 is pivotal in initiating transcription by RNA polymerase II, regulating the early steps of gene expression.
TAF1 responds to cellular signals and stress, adapting gene expression to meet cellular needs and challenges.
TAF1 plays a role in chromatin remodeling, making DNA accessible for transcription and regulating gene activity.
Changes in TAF1 can influence key cellular processes like the cell cycle and programmed cell death.
TAF1 is integral to the TFIID complex, essential for accurate and efficient transcription initiation.
Mutations in TAF1 are linked to neurodevelopmental disorders, affecting brain development and function.
Customer Reviews (3)
Write a reviewExpertise in peptide synthesis, accelerates our peptide-based research.
Swift protein quantification, improves data reliability in our work.
Reliable protein crystallography, key for our structural biology research.
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