Native Human Transferrin Receptor

• Cat.No.: TFRC-249H
• Product Overview: Purified Native Human Serum Transferrin Receptor.

Specification

• Description: Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Transferrin Receptor imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis.Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis
• Source: Human Serum
• Species: Human
• Form: Liquid - 25 mM TRIS buffer, 0.15 M NaCl, 0.09% Sodium Azide, pH: 8.0 + or - 0.2
• Storage: Store at -20 °C.

Gene Information

• Gene Name: TFRC transferrin receptor (p90, CD71) [ Homo sapiens ]
• Official Symbol: TFRC
• Synonyms: TFRC; transferrin receptor (p90, CD71); transferrin receptor protein 1; CD71; TFR1; T9; TR; TFR; p90; TRFR
• Gene ID: 7037
• mRNA Refseq: NM_001128148
• Protein Refseq: NP_001121620
• MIM: 190010
• UniProt ID: P02786
• Chromosome Location: 3q26.2-qter
• Pathway: Clathrin derived vesicle budding, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem
• Function: Hsp70 protein binding; chaperone binding; peptidase activity; receptor activity; transferrin receptor activity