Recombinant Human HIF1A, GST-tagged
Cat.No. : | HIF1A-106H |
Product Overview : | Human HIF1A full-length ORF ( NP_851397.1, 1 a.a. - 735 a.a.) recombinant protein with GST-tag at N-terminal. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Description : | Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1β subunit and one of three subunits(Hif-1α, Hif-2( or Hif-3)). The activation of Hif-1( is closely associated with a variety of tumors and oncogenic pathways. Hif-1( consists of DNA binding domain(DBD domain), Dimerization domain and C-terminla regulatiory domains, including two transactivation domains(TAD), an oxygen-dependent degradation(ODD) domain, and inhibitory domains. |
Source : | wheat germ |
Species : | Human |
Tag : | GST |
Form : | Liquid |
Molecular Mass : | 109.1 kDa |
AA Sequence : | MEGAGGANDKKKISSERRKEKSRDA ARSRRSKESEVFYELAHQLPLPHNV SSHLDKASVMRLTISYLRVRKLLDA GDLDIEDDMKAQMNCFYLKALDGFV MVLTDDGDMIYISDNVNKYMGLTQF ELTGHSVFDFTHPCDHEEMREMLTH RNGLVKKGKEQNTQRSFFLRMKCTL TSRGRTMNIKSATWKVLHCTGHIHV YDTNSNQPQCGYKKPPMTCLVLICE PIPHPSNIEIPLDSKTFLSRHSLDM KFSYCDERITELMGYEPEELLGRSI YEYYHALDSDHLTKTHHDMFTKGQV TTGQYRMLAKRGGYVWVETQATVIY NTKNSQPQCIVCVNYVVSGIIQHDL IFSLQQTECVLKPVESSDMKMTQLF TKVESEDTSSLFDKLKKEPDALTLL APAAGDTIISLDFGSNDTETDDQQL EEVPLYNDVMLPSPNEKLQNINLAM SPLPTAETPKPLRSSADPALNQEVA LKLEPNPESLELSFTMPQIQDQTPS PSDGSTRQSSPEPNSPSEYCFYVDS DMVNEFKLELVEKLFAEDTEAKNPF STQDTDLDLEMLAPYIPMDDDFQLR SFDQLSPLESSSASPESASPQSTVT VFQQTQIQEPTANATTTTATTDELK TVTKDRMEDIKILIASPSPTHIHKE TTSATSSPYRDTQSRTASPNRAGKG VIEQTEKSHPRSPNVLSVALSQRTT VPEEELNPKILALQNAQRKRKMEHD GSLFQAVGII |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [ Homo sapiens ] |
Official Symbol : | HIF1A |
Synonyms : | HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; bHLHe78; HIF 1alpha; HIF1; MOP1; PASD8; HIF-1-alpha; member of PAS protein 1; ARNT interacting protein; ARNT-interacting protein; member of PAS superfamily 1; PAS domain-containing protein 8; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); HIF-1alpha; HIF1-ALPHA; |
Gene ID : | 3091 |
mRNA Refseq : | NM_001243084 |
Protein Refseq : | NP_001230013 |
MIM : | 603348 |
UniProt ID : | Q16665 |
Chromosome Location : | 14q23.2 |
Pathway : | Adipogenesis, organism-specific biosystem; Angiogenesis, organism-specific biosystem; Circadian Clock, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; |
Function : | Hsp90 protein binding; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; protein kinase binding; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; contributes_to sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding; |
Products Types
◆ Recombinant Protein | ||
HIF1A-0487H | Recombinant Human HIF1A Protein (E2-N826), His/Strep tagged | +Inquiry |
HIF1A-3111H | Recombinant Human HIF1A Protein, His (Fc)-Avi-tagged | +Inquiry |
HIF1A-0486H | Recombinant Human HIF1A Protein (E2-N826), Tag Free | +Inquiry |
HIF1A-22H | Recombinant Human HIF1A Protein, T7-His-TEV-tagged | +Inquiry |
HIF1A-2240H | Recombinant Human HIF1A Protein, His-tagged | +Inquiry |
◆ Lysates | ||
HIF1A-787HCL | Recombinant Human HIF1A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionHIF1A shifts cellular metabolism from oxidative phosphorylation to glycolysis, conserving oxygen but producing less energy.
HIF1A modulates immune cell function, influencing responses like inflammation and immune cell migration in hypoxic tissues.
HIF1A upregulates the expression of angiogenic factors, promoting blood vessel formation to improve oxygen supply.
In cancer, HIF1A promotes tumor growth, survival, and metastasis under low oxygen conditions.
HIF1A activates the transcription of genes involved in oxygen delivery and metabolic adaptation to hypoxia.
Under normoxic conditions, HIF1A is rapidly degraded, but under hypoxia, it stabilizes, translocates to the nucleus, and activates target genes.
Therapeutic strategies targeting HIF1A aim to inhibit its activity in cancer or enhance it in conditions like ischemic heart disease.
Customer Reviews (3)
Write a reviewReliable product, satisfied customer.
Good value for money.
Product exceeded expectations.
Ask a Question for All HIF1A Products
Required fields are marked with *
My Review for All HIF1A Products
Required fields are marked with *
Inquiry Basket