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Recombinant Human HIF1A, GST-tagged

Cat.No. : HIF1A-106H
Product Overview : Human HIF1A full-length ORF ( NP_851397.1, 1 a.a. - 735 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1β subunit and one of three subunits(Hif-1α, Hif-2( or Hif-3)). The activation of Hif-1( is closely associated with a variety of tumors and oncogenic pathways. Hif-1( consists of DNA binding domain(DBD domain), Dimerization domain and C-terminla regulatiory domains, including two transactivation domains(TAD), an oxygen-dependent degradation(ODD) domain, and inhibitory domains.
Source : wheat germ
Species : Human
Tag : GST
Form : Liquid
Molecular Mass : 109.1 kDa
AA Sequence : MEGAGGANDKKKISSERRKEKSRDA ARSRRSKESEVFYELAHQLPLPHNV SSHLDKASVMRLTISYLRVRKLLDA GDLDIEDDMKAQMNCFYLKALDGFV MVLTDDGDMIYISDNVNKYMGLTQF ELTGHSVFDFTHPCDHEEMREMLTH RNGLVKKGKEQNTQRSFFLRMKCTL TSRGRTMNIKSATWKVLHCTGHIHV YDTNSNQPQCGYKKPPMTCLVLICE PIPHPSNIEIPLDSKTFLSRHSLDM KFSYCDERITELMGYEPEELLGRSI YEYYHALDSDHLTKTHHDMFTKGQV TTGQYRMLAKRGGYVWVETQATVIY NTKNSQPQCIVCVNYVVSGIIQHDL IFSLQQTECVLKPVESSDMKMTQLF TKVESEDTSSLFDKLKKEPDALTLL APAAGDTIISLDFGSNDTETDDQQL EEVPLYNDVMLPSPNEKLQNINLAM SPLPTAETPKPLRSSADPALNQEVA LKLEPNPESLELSFTMPQIQDQTPS PSDGSTRQSSPEPNSPSEYCFYVDS DMVNEFKLELVEKLFAEDTEAKNPF STQDTDLDLEMLAPYIPMDDDFQLR SFDQLSPLESSSASPESASPQSTVT VFQQTQIQEPTANATTTTATTDELK TVTKDRMEDIKILIASPSPTHIHKE TTSATSSPYRDTQSRTASPNRAGKG VIEQTEKSHPRSPNVLSVALSQRTT VPEEELNPKILALQNAQRKRKMEHD GSLFQAVGII
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [ Homo sapiens ]
Official Symbol : HIF1A
Synonyms : HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; bHLHe78; HIF 1alpha; HIF1; MOP1; PASD8; HIF-1-alpha; member of PAS protein 1; ARNT interacting protein; ARNT-interacting protein; member of PAS superfamily 1; PAS domain-containing protein 8; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); HIF-1alpha; HIF1-ALPHA;
Gene ID : 3091
mRNA Refseq : NM_001243084
Protein Refseq : NP_001230013
MIM : 603348
UniProt ID : Q16665
Chromosome Location : 14q23.2
Pathway : Adipogenesis, organism-specific biosystem; Angiogenesis, organism-specific biosystem; Circadian Clock, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem;
Function : Hsp90 protein binding; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; protein kinase binding; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; contributes_to sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does HIF1A contribute to metabolic reprogramming in cells? 09/01/2022

HIF1A shifts cellular metabolism from oxidative phosphorylation to glycolysis, conserving oxygen but producing less energy.

How does HIF1A influence immune responses under hypoxic conditions? 07/10/2021

HIF1A modulates immune cell function, influencing responses like inflammation and immune cell migration in hypoxic tissues.

What role does HIF1A play in angiogenesis? 04/28/2021

HIF1A upregulates the expression of angiogenic factors, promoting blood vessel formation to improve oxygen supply.

In what way is HIF1A implicated in cancer progression? 09/14/2020

In cancer, HIF1A promotes tumor growth, survival, and metastasis under low oxygen conditions.

What is the primary function of HIF1A in response to hypoxia? 08/27/2018

HIF1A activates the transcription of genes involved in oxygen delivery and metabolic adaptation to hypoxia.

How is HIF1A regulated at the post-translational level? 06/17/2018

Under normoxic conditions, HIF1A is rapidly degraded, but under hypoxia, it stabilizes, translocates to the nucleus, and activates target genes.

What therapeutic strategies are being developed to target HIF1A in diseases? 02/13/2018

Therapeutic strategies targeting HIF1A aim to inhibit its activity in cancer or enhance it in conditions like ischemic heart disease.

Customer Reviews (3)

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Reviews
03/19/2022

    Reliable product, satisfied customer.

    03/28/2021

      Good value for money.

      11/07/2018

        Product exceeded expectations.

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