Recombinant Mouse Angpt2, FLAG-tagged

• Cat.No.: Angpt2-88M
• Product Overview: Mouse angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG-tag.

Specification

• Description: Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.
• Source: HEK293 Cells
• Species: Mouse
• Tag: FLAG
• Form: Lyophilized. Contains PBS with trehalose and Brij35.
• Molecular Mass: ~70kDa (SDS-PAGE)
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Concentration: 0.1 mg /ml after reconstitution.

Gene Information

• Gene Name: Angpt2 angiopoietin 2 [ Mus musculus ]
• Official Symbol: Angpt2
• Synonyms: ANGPT2; angiopoietin 2; angiopoietin-2; Ang2; Agpt2; Ang-2
• Gene ID: 11601
• mRNA Refseq: NM_007426
• Protein Refseq: NP_031452
• Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Tie2 Signaling, organism-specific biosystem
• Function: metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding; vascular endothelial growth factor receptor binding