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Active Recombinant Human PDCD1LG2, Fc-tagged

Cat.No. : PDCD1LG2-172H
Product Overview : The extracellular domain of human CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc region of a mutant human IgG1.
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Description : T cells require a signal induced by the engagement of the T cell receptor and a “costimulatory” signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 [PD-L2] is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
Source : CHO Cells
Species : Human
Tag : Fc
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Shows the biological function of the CD273 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
Purity : ≥98% (SDS-PAGE)
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.
Gene Name : PDCD1LG2 programmed cell death 1 ligand 2 [ Homo sapiens ]
Official Symbol : PDCD1LG2
Synonyms : PDCD1LG2; programmed cell death 1 ligand 2; B7 dendritic cell molecule; B7 DC; bA574F11.2; Btdc; CD273; PD L2; PDL2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7DC; PD-L2; PDCD1L2; MGC142238; MGC142240;
Gene ID : 80380
mRNA Refseq : NM_025239
Protein Refseq : NP_079515
MIM : 605723
UniProt ID : Q9BQ51
Chromosome Location : 9p24.2
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem;
Function : molecular_function; protein tyrosine phosphatase activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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