Active Recombinant Human IL8, Fc-tagged
Cat.No. : | IL8-324H |
Product Overview : | The extracellular domain of human IL-8 (aa 23-99) is fused to the N-terminus of the Fc region of a mutant human IgG1. |
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Description : | Interleukin-8 (IL-8) was originally discovered as a neutrophil chemotactic and activating factor and is a member of the alpha (CXC) subfamily of chemokines (including also platelet factor 4, GRO, IP-10, etc.). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes and various tumor cell lines, produce IL-8 in response to a wide variety of proinflammatory stimuli such as exposure to IL-1, TNF, LPS and viruses. IL-8 has a wide range of other proinflammatory effects. It is a potent chemoattractant for neutrophils and causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 was also reported to be angiogenic both in vivo and in vitro. |
Source : | CHO Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Shows the biological function of the IL-8 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. |
Gene Name : | IL8 interleukin 8 [ Homo sapiens ] |
Official Symbol : | IL8 |
Synonyms : | IL8; interleukin 8; interleukin-8; 3 10C; alveolar macrophage chemotactic factor I; AMCF I; b ENAP; beta endothelial cell derived neutrophil activating peptide; chemokine (C X C motif) ligand 8; CXCL8; GCP 1; GCP1; granulocyte chemotactic protein 1; IL 8; K60; LECT; LUCT; lung giant cell carcinoma derived chemotactic protein; lymphocyte derived neutrophil activating peptide; LYNAP; MDNCF; MONAP; monocyte derived neutrophil chemotactic factor; monocyte derived neutrophil activating peptide; NAF; NAP 1; NAP1; neutrophil activating peptide 1; SCYB8; TSG 1; tumor necrosis factor induced gene 1; emoctakin; T-cell chemotactic factor; neutrophil-activating peptide 1; chemokine (C-X-C motif) ligand 8; beta-thromboglobulin-like protein; tumor necrosis factor-induced gene 1; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; small inducible cytokine subfamily B, member 8; lung giant cell carcinoma-derived chemotactic protein; beta endothelial cell-derived neutrophil activating peptide; GCP-1; NAP-1; |
Gene ID : | 3576 |
mRNA Refseq : | NM_000584 |
Protein Refseq : | NP_000575 |
MIM : | 146930 |
UniProt ID : | P10145 |
Chromosome Location : | 4q13-q21 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Activation of Genes by ATF4, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; |
Function : | chemokine activity; interleukin-8 receptor binding; protein binding; |
Products Types
◆ Lysates | ||
IL8-3004HCL | Recombinant Human IL8 cell lysate | +Inquiry |
IL8-3002HCL | Recombinant Human IL8 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionActs as a chemical messenger in the immune system that regulates inflammation and attracts immune cells such as white blood cells.
Regulating tumor microenvironment, promoting tumor growth and metastasis, and can be used in tumor therapy research.
IL8 plays a role in regulating and promoting the migration and activation of inflammatory cells in the inflammatory response.
Can be used to treat inflammatory diseases (such as rheumatoid arthritis, psoriasis), tumors (such as lung cancer, breast cancer) and other diseases.
Yes, IL8 is closely related to immunotherapy, which can enhance the role of the immune system and assist in the treatment of certain diseases.
IL8 is generally prepared by gene recombination technology, and the IL8 gene is introduced into the appropriate expression system, and then expressed and purified.
Customer Reviews (3)
Write a reviewIL8 has good fluorescence and absorption properties.
NIPBL has good stability in different environments and is not easy to degrade.
Through animal models or in vitro experiments to evaluate the mechanism of the recombinant protein in related diseases, we found that the effect is very good.
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