Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human KL, Fc-tagged

Cat.No. : KL-386H
Product Overview : Signal peptide and the extracellular domain of human Klotho (aa 1-981) are fused at the C-terminus to the Fc portion of human IgG1.
  • Specification
  • Gene Information
  • Related Products
Description : Klotho is involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. It is an essential factor for the specific interaction between FGF23 and FGFR1. The secreted Klotho protein can regulate multiple growth factor signaling pathways, including insulin/IGF-1 and Wnt, and the activity of multiple ion channels. Klotho protein protects cells and tissues from oxidative stress. Understanding of Klotho protein function is expected to provide new insights into the molecular basis for aging, phosphate/vitamin D metabolism, cancer and stem cell biology.
Source : HEK293 Cells
Species : Human
Tag : Fc
Form : Liquid. 0.2μm-filtered solution in PBS.
Molecular Mass : ~110kDa (SDS-PAGE)
Purity : ≥95% (SDS-PAGE)
Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Concentration : ~0.15mg/ml
Gene Name : KL klotho [ Homo sapiens ]
Official Symbol : KL
Synonyms : KL; klotho;
Gene ID : 9365
mRNA Refseq : NM_004795
Protein Refseq : NP_004786
UniProt ID : Q9UEF7
Chromosome Location : 13q12
Pathway : Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem;
Function : beta-glucosidase activity; beta-glucuronidase activity; cation binding; fibroblast growth factor binding; fibroblast growth factor receptor binding; hormone activity; signal transducer activity; vitamin D binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does KL protein affect cognitive function? 04/08/2022

KL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.

Are there any KL protein-based therapies available for clinical use? 04/07/2022

Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.

Can KL protein supplementation slow down the aging process? 10/25/2021

While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.

How is KL protein measured in clinical settings? 07/19/2018

KL protein levels can be measured in blood and urine samples using various laboratory techniques.

Are there any clinical trials exploring KL protein-based therapies? 04/28/2016

Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.

Customer Reviews (3)

Write a review
Reviews
01/31/2021

    The KL protein's reliability and ease of use have made it an essential component of my structural investigations.

    01/22/2019

      Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

      07/22/2016

        Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.

        Ask a Question for All KL Products

        Required fields are marked with *

        My Review for All KL Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends