Active Recombinant Human RETN, FLAG-tagged

• Cat.No.: RETN-475H
• Product Overview: Human resistin (aa 20-108) is fused at the N-terminus to a FLAG-tag.

Specification

• Description: The adipocytokine resistin which belongs to a family of cysteine-rich C-terminal proteins known as resistin-like molecules (RELM; RELM-alpha/FIZZ 1 and RELM-beta/FIZZ 2) of FIZZ (found in inflammatory zone) are thought to be involved in inflammatory processes. Previous studies in mice showed that resistin impairs glucose tolerance and insulin action. In addition, resistin also inhibits adipogenesis in murine 3T3-L1 cells. Therefore resistin has also been proposed as an adipocyte-secreted factor thought to link obesity and T2DM.
• Source: HEK293 Cells
• Species: Human
• Tag: FLAG
• Form: Liquid. 0.2μm-filtered solution in PBS, pH 7.2.
• Bio-activity: Inhibits insulin-stimulated glucose uptake in L6 skeletal muscle cells.
• Molecular Mass: ~12kDa (SDS-PAGE)
• Purity: ≥90% (SDS-PAGE)
• Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Concentration: 0.2mg/ml

Gene Information

• Gene Name: RETN resistin [ Homo sapiens ]
• Official Symbol: RETN
• Synonyms: RETN; resistin; ADSF; FIZZ3; RETN1; resistin delta2; found in inflammatory zone 3; cysteine-rich secreted protein FIZZ3; adipose tissue-specific secretory factor; cysteine-rich secreted protein A12-alpha-like 2; c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1; RSTN; XCP1; MGC126603; MGC126609
• Gene ID: 56729
• mRNA Refseq: NM_001193374
• Protein Refseq: NP_001180303
• MIM: 605565
• UniProt ID: Q9HD89
• Chromosome Location: 19p13.2
• Pathway: Adipogenesis, organism-specific biosystem
• Function: hormone activity; hormone activity