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Recombinant Human KLB, Fc-tagged

Cat.No. : KLB-537H
Product Overview : The extracellular domain of human βKlotho (aa 1-996) is fused at the C-terminus to the Fc portion of human IgG1.
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Description : βKlotho (KLB) induces ERK1/2 phosphorylation in response to FGF19 treatment and significantly increases the interactions between FGF19 and FGFR4. It is a cofactor for the interaction of FGF21 with FGF receptor 1c in adipocytes, which allows FGF21 to stimulate GLUT1 expression, upregulating adipocyte insulin-dependent glucose uptake. bKlotho contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis.
Source : HEK293 Cells
Species : Human
Tag : Fc
Form : Liquid. 0.2μm-filtered solution in PBS.
Molecular Mass : ~180kDa (SDS-PAGE)
Purity : ≥95% (SDS-PAGE)
Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Concentration : 0.05mg/ml
Gene Name : KLB klotho beta [ Homo sapiens ]
Official Symbol : KLB
Synonyms : KLB; klotho beta; beta-klotho; betaKlotho; klotho beta like; klotho beta-like protein; BKL; MGC142213;
Gene ID : 152831
mRNA Refseq : NM_175737
Protein Refseq : NP_783864
MIM : 611135
UniProt ID : Q86Z14
Chromosome Location : 4p14
Pathway : Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem;
Function : catalytic activity; cation binding; fibroblast growth factor binding; hydrolase activity, hydrolyzing O-glycosyl compounds;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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