Recombinant Human PDGFA
Cat.No. : | PDGFA-121H |
Product Overview : | Recombinant Human Platelet-Derived Growth Factor AA is a homodimeric, non-glycosylated produced inE.Coli, polypeptide chain containing 2 x 125 amino acids and having a total molecular mass of 28511 Dalton. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PDGFA-121H |
Description : | PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. |
Source : | Escherichia Coli. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 97.0% as determined by: (a) Analysis by RP-HPLC; (b) Analysis by SDS-PAGE. |
Formulation : | The protein was lyophilized with no additives. |
Solubility : | It is recommended to reconstitute the lyophilized Platelet-derived Growth Factor-AA in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Specific Activity : | The ED50, calculated by the dose-dependant proliferation of murine BALB/c 3T3 indicator cells (measured by 3H-thymidine uptake) is < 1 ng/ml, corresponding to a Specific Activity of 1 MIU/mg. |
Stability : | Lyophilized Platelet-Derived Growth Factor AA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PDGF-AA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | PDGFA platelet-derived growth factor alpha polypeptide [ Homo sapiens ] |
Synonyms : | platelet-derived growth factor alpha polypeptide; PDGF1; PDGF-A; PDGFA; platelet-derived growth factor alpha; PDGF A-chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; PDGF1; PDGF subunit A; Platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide |
Gene ID : | 5154 |
mRNA Refseq : | NM_002607 |
Protein Refseq : | NP_002598 |
MIM : | 173430 |
UniProt ID : | P04085 |
Chromosome Location : | 7p22 |
Pathway : | Focal adhesion; Gap junction; Glioma; MAPK signaling pathway; Melanoma; Prostate cancer; Regulation of actin cytoskeleton; Hemostasis |
Function : | cell surface binding; collagen binding; growth factor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; contributes_to platelet-derived growth factor receptor binding; platelet-derived growth factor receptor binding; protein heterodimerization activity; protein homodimerization activity |
Products Types
◆ Recombinant Protein | ||
PDGFA-514M | Recombinant Mouse PDGFA protein(Ser87-Arg196), His-tagged | +Inquiry |
PDGFA-32H | Recombinant Human PDGFA Protein | +Inquiry |
PDGFA-3997R | Recombinant Rat PDGFA Protein, His (Fc)-Avi-tagged | +Inquiry |
PDGFA-940R | Recombinant Rat PDGFA Protein (Ser87-Arg196), His-tagged | +Inquiry |
Pdgfa-317P | Active Recombinant Mouse Pdgfaa Protein (125 aa) | +Inquiry |
◆ Lysates | ||
PDGFA-3337HCL | Recombinant Human PDGFA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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