Active Recombinant Human TGFB1

• Cat.No.: TGFB1-120H
• Product Overview: Recombinant human TGF-b1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

Specification

• Description: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
• Source: CHO cells
• Species: Human
• Bio-activity: Determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤0.05 ng/ml, corresponding to a specific activity of ≥2 x 10^7 units/mg.
• Molecular Mass: 25.0 kDa
• AA Sequence: ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
• Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
• Publication:
  lncRNA H19 is involved in TGF-β1-induced epithelial to mesenchymal transition in bovine epithelial cells through PI3K/AKT Signaling Pathway. (2017)
  lncRNA H19 mediates TGF-β1-induced epithelial to mesenchymal transition in bovine epithelial cells through PI3K/AKT Signaling Pathway. (2017)
  Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats (2018)

Gene Information

• Gene Name: TGFB1 transforming growth factor, beta 1 [ Homo sapiens(human) ]
• Official Symbol: TGFB1
• Synonyms: TGFB1; CED; LAP; DPD1; TGFB; TGFbeta; transforming growth factor, beta 1; transforming growth factor beta-1; TGF-beta-1; TGF-beta 1 protein; latency-associated peptide
• Gene ID: 7040
• mRNA Refseq: NM_000660
• Protein Refseq: NP_000651
• MIM: 190180
• UniProt ID: P01137
• Chromosome Location: 19q13.1
• Pathway: ACE Inhibitor Pathway; Cardiac Progenitor Differentiation; Chagas disease (American trypanosomiasis)
• Function: enzyme binding; protein N-terminus binding; protein heterodimerization activity