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Recombinant Human AGRN protein, His-tagged

Cat.No. : AGRN-132H
Product Overview : Recombinant Human AGRN(Thr30-Arg1102) fused with His tag at C-terminal was expressed in CHO.
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  • Gene Information
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Source : CHO
Species : Human
Tag : His
Predicted N Terminal : Thr30
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Molecular Mass : Predicted Molecular Mass: 113 kDa;SDS-PAGE: 138-181 kDa, reducing conditions
Endotoxin : <0.10 eu per 1 μg of the protein by the lal>
Purity : >95%, by SDS-PAGE with silver staining.
Storage : Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 500 μg/mL in PBS.
Gene Name : AGRN agrin [ Homo sapiens ]
Official Symbol : AGRN
Synonyms : AGRN; agrin; AGRIN; agrin proteoglycan;
Gene ID : 375790
mRNA Refseq : NM_198576
Protein Refseq : NP_940978
MIM : 103320
UniProt ID : O00468
Chromosome Location : 1p36.33
Pathway : Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem; NCAM1 interactions, organism-specific biosystem;
Function : acetylcholine receptor regulator activity; laminin binding; protein binding; structural constituent of cytoskeleton;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can AGRN be used as a diagnostic marker for neurological diseases? 11/19/2022

The measurement of AGRN levels or its isoforms in biological fluids or tissues may hold potential as diagnostic markers for certain neurological disorders, although further research is needed.

How is AGRN involved in neuromuscular junction formation? 06/01/2022

AGRN interacts with specific receptors on the muscle and nerve cells, initiating a signaling cascade that leads to the clustering of acetylcholine receptors and the formation and maintenance of the NMJ.

Is AGRN involved in other organ systems besides the neuromuscular junction? 04/23/2022

Yes, AGRN has been shown to have roles outside of the NMJ, including in the development of the central nervous system, kidneys, and cardiovascular system.

What are the isoforms of AGRN? 10/16/2021

AGRN exists in multiple isoforms generated by alternative splicing. The most well-known isoforms include the neural isoforms (Agrin-N) and the muscle-specific isoforms (Agrin-M).

What is the structure of AGRN? 09/19/2021

AGRN consists of several functional domains, including N-terminal laminin G-like (LG) domains, central EGF-like repeats, a C-terminal domain, and a heparin-binding site.

How is AGRN involved in cancer progression? 12/04/2019

AGRN has been found to promote tumor cell migration, invasion, and metastasis by interacting with receptors and signaling pathways that regulate cell adhesion, migration, and angiogenesis.

How is AGRN expression regulated? 11/23/2018

AGRN expression is tightly regulated during development and can be influenced by various signaling pathways, including Wnt, BMP, and Notch signaling.

What are the receptor molecules for AGRN? 08/16/2018

AGRN interacts with two major receptors: muscle-specific kinase (MuSK) on the postsynaptic membrane and low-density lipoprotein receptor-related protein 4 (LRP4) on the presynaptic membrane.

How is AGRN involved in synaptic plasticity? 08/11/2018

AGRN plays a role in regulating synaptic plasticity by modulating the structure and function of synapses, including their strength and stability.

How is AGRN involved in synaptic maturation? 06/05/2018

AGRN regulates the maturation and stabilization of synapses by promoting the clustering of postsynaptic receptors and facilitating the development of pre- and postsynaptic specializations.

Customer Reviews (5)

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Reviews
11/23/2022

    The packaging was secure, and the proteins maintained their integrity and activity upon arrival.

    12/03/2021

      I highly recommend their products for researchers seeking reliable reagents.

      09/14/2021

        They offer excellent value for the price.

        07/09/2021

          We rely on this protein for its consistent performance.

          05/22/2021

            I am extremely satisfied with the prompt delivery of the proteins.

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