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Recombinant Human CD200, His-tagged

Cat.No. : CD200-202H
Product Overview : CD200, 31-232aa, Human, His tag, E.coli
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  • Gene Information
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Description : CD200 is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. Recombinant human CD200 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Molecular Mass : 24.8kDa (225aa)
Protein length : 31-232aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSQVQVVTQ DEREQLYTPA SLKCSLQNAQ EALIVTWQKK KAVSPENMVT FSENHGVVIQ PAYKDKINIT QLGLQNSTIT FWNITLEDEG CYMCLFNTFG FGKISGTACL TVYVQPIVSL HYKFSEDHLN ITCSATARPA PMVFWKVPRS GIENSTVTLS HPNGTTSVTS ILHIKDPKNQ VGKEVICQVL HLGTVTDFKQ TVNKG
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : CD200 CD200 molecule [ Homo sapiens ]
Official Symbol : CD200
Synonyms : CD200; CD200 molecule; antigen identified by monoclonal MRC OX 2 , CD200 antigen , MOX1, MOX2; OX-2 membrane glycoprotein; MRC; OX 2; CD200 antigen; MRC OX-2 antigen; antigen identified by monoclonal MRC OX-2; MOX1; MOX2; OX-2;
Gene ID : 4345
mRNA Refseq : NM_001004196
Protein Refseq : NP_001004196
MIM : 155970
UniProt ID : P41217
Chromosome Location : 3
Pathway : Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem;
Function : identical protein binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CD200 contribute to the regulation of bone marrow and hematopoietic stem cell niches? 10/04/2022

CD200 regulates bone marrow and hematopoietic environments, supporting stem cell maintenance and differentiation.

How does CD200 influence tumor immune evasion and the tumor microenvironment in cancer? 07/10/2021

CD200 contributes to immune evasion in cancers, affecting tumor progression and response to immunotherapy.

What role does CD200 play in the suppression of inflammatory responses in autoimmune diseases? 04/06/2021

CD200 plays a role in suppressing inflammatory responses, which is crucial in autoimmune disease management.

What are the effects of CD200 dysregulation on tissue graft rejection and transplant tolerance? 02/09/2019

Dysregulation of CD200 affects tissue graft rejection, influencing transplant tolerance and success.

How do alterations in CD200 expression impact the aging process and age-related immune changes? 09/17/2018

Changes in CD200 expression impact the aging immune system, affecting age-related immune regulation and function.

What is the impact of CD200 expression on neuroinflammatory processes and neurodegenerative diseases? 03/20/2018

CD200 expression influences neuroinflammatory processes, potentially impacting neurodegenerative diseases.

How does CD200 interact with its receptor CD200R, and what are the implications for immune regulation? 03/18/2018

CD200 interacts with CD200R to modulate immune responses, promoting immune tolerance and reducing inflammation.

Customer Reviews (3)

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Reviews
08/01/2022

    Swift protein sequencing, helps identify unknown proteins.

    05/04/2022

      Great protein crystallization services, key for structural biology.

      05/02/2019

        Invaluable protein-protein interaction assays, integral for research.

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