Recombinant Human Interleukin 8
Cat.No. : | IL8-53H |
Product Overview : | Recombinant Human Interleukin-8 produced inYeastis a single, glycosylated polypeptide chain containing 79 amino acids and having a molecular mass of 9 kDa. The IL-8 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL8-53H |
Description : | Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor. |
Source : | Yeast. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Purity : | Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Formulation : | Lyophilized from a concentrated (1 mg/ml) solution in water containing 20 mM sodium phosphate buffer pH-8. |
Solubility : | It is recommended to reconstitute the lyophilized Interleukin 8 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
Specific Activity : | Specific Activity of IL8 in chemotaxis of donor PBL neutrophils, threshold concentration corresponding to 25 ng/ml. |
Stability : | Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL8 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | IL8 interleukin 8 [ Homo sapiens ] |
Synonyms : | IL8; interleukin 8; NAF; GCP1; LECT; LUCT; NAP1; CXCL8; LYNAP; MDNCF; MONAP; NAP-1; SCYB8; SG-1; 3-10C; AMCF-I; NAF; b-ENAP; K60; Emoctakin; TSG-1; chemokine (C-X-C motif) ligand 8;Monocyte-derived neutrophil chemotactic factor; T-cell chemotactic factor; Neutrophil-activating protein 1; Protein 3-10C; Granulocyte chemotactic protein 1; Monocyte-derived neutrophil-activating peptide;MDNCF-a;IL8/NAP1 form I; GCP/IL-8 protein IV; IL8/NAP1 form II; GCP/IL-8 protein II; (Ala-IL-8)77; IL-8(5-57); IL-8(6-77); IL-8(5-77); Lymphocyte-derived neutrophil-activating factor; MDNCF-c; IL8/NAP1 form III; GCP/IL-8 protein I; (Ser-IL-8)72; IL-8(7-77); IL-8(8-77); IL-8(9-77); IL8/NAP1 form IV; GCP/IL-8 protein V ; IL8/NAP1 form V; GCP/IL-8 protein VI; IL8/NAP1 form VI; GCP/IL-8 protein III; Monocyte-derived neutrophil chemotactic factor; beta-thromboglobulin-like protein; small inducible cytokine subfamily B, member 8 |
Gene ID : | 3576 |
mRNA Refseq : | NM_000584 |
Protein Refseq : | NP_000575 |
MIM : | 146930 |
UniProt ID : | P10145 |
Chromosome Location : | 4q13-q21 |
Pathway : | Bladder cancer; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Pathways in cancer; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Signaling by GPCR |
Function : | chemokine activity;interleukin-8 receptor binding;protein binding |
Products Types
◆ Recombinant Protein | ||
IL8-189H | Recombinant Human IL8 Protein | +Inquiry |
il8-4414A | Recombinant Atlantic Salmon il8 Protein | +Inquiry |
IL8-190P | Recombinant Porcine IL8 Protein | +Inquiry |
IL8-4444H | Recombinant Human IL8 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL8-580S | Recombinant Sheep IL8 Protein (23-101 aa), His-tagged | +Inquiry |
◆ Lysates | ||
IL8-3004HCL | Recombinant Human IL8 cell lysate | +Inquiry |
IL8-3002HCL | Recombinant Human IL8 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionActs as a chemical messenger in the immune system that regulates inflammation and attracts immune cells such as white blood cells.
Regulating tumor microenvironment, promoting tumor growth and metastasis, and can be used in tumor therapy research.
IL8 plays a role in regulating and promoting the migration and activation of inflammatory cells in the inflammatory response.
Can be used to treat inflammatory diseases (such as rheumatoid arthritis, psoriasis), tumors (such as lung cancer, breast cancer) and other diseases.
Yes, IL8 is closely related to immunotherapy, which can enhance the role of the immune system and assist in the treatment of certain diseases.
IL8 is generally prepared by gene recombination technology, and the IL8 gene is introduced into the appropriate expression system, and then expressed and purified.
Customer Reviews (3)
Write a reviewIL8 has good fluorescence and absorption properties.
NIPBL has good stability in different environments and is not easy to degrade.
Through animal models or in vitro experiments to evaluate the mechanism of the recombinant protein in related diseases, we found that the effect is very good.
Ask a Question for All IL8 Products
Required fields are marked with *
My Review for All IL8 Products
Required fields are marked with *
Inquiry Basket