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Recombinant Human Interleukin 8

Cat.No. : IL8-53H
Product Overview : Recombinant Human Interleukin-8 produced inYeastis a single, glycosylated polypeptide chain containing 79 amino acids and having a molecular mass of 9 kDa. The IL-8 is purified by proprietary chromatographic techniques.
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Cat. No. : IL8-53H
Description : Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.
Source : Yeast.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : Lyophilized from a concentrated (1 mg/ml) solution in water containing 20 mM sodium phosphate buffer pH-8.
Solubility : It is recommended to reconstitute the lyophilized Interleukin 8 in sterile 18 MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Specific Activity : Specific Activity of IL8 in chemotaxis of donor PBL neutrophils, threshold concentration corresponding to 25 ng/ml.
Stability : Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL8 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : IL8 interleukin 8 [ Homo sapiens ]
Synonyms : IL8; interleukin 8; NAF; GCP1; LECT; LUCT; NAP1; CXCL8; LYNAP; MDNCF; MONAP; NAP-1; SCYB8; SG-1; 3-10C; AMCF-I; NAF; b-ENAP; K60; Emoctakin; TSG-1; chemokine (C-X-C motif) ligand 8;Monocyte-derived neutrophil chemotactic factor; T-cell chemotactic factor; Neutrophil-activating protein 1; Protein 3-10C; Granulocyte chemotactic protein 1; Monocyte-derived neutrophil-activating peptide;MDNCF-a;IL8/NAP1 form I; GCP/IL-8 protein IV; IL8/NAP1 form II; GCP/IL-8 protein II; (Ala-IL-8)77; IL-8(5-57); IL-8(6-77); IL-8(5-77); Lymphocyte-derived neutrophil-activating factor; MDNCF-c; IL8/NAP1 form III; GCP/IL-8 protein I; (Ser-IL-8)72; IL-8(7-77); IL-8(8-77); IL-8(9-77); IL8/NAP1 form IV; GCP/IL-8 protein V ; IL8/NAP1 form V; GCP/IL-8 protein VI; IL8/NAP1 form VI; GCP/IL-8 protein III; Monocyte-derived neutrophil chemotactic factor; beta-thromboglobulin-like protein; small inducible cytokine subfamily B, member 8
Gene ID : 3576
mRNA Refseq : NM_000584
Protein Refseq : NP_000575
MIM : 146930
UniProt ID : P10145
Chromosome Location : 4q13-q21
Pathway : Bladder cancer; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Pathways in cancer; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway; Signaling by GPCR
Function : chemokine activity;interleukin-8 receptor binding;protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of IL8 in the immune system? 08/31/2021

Acts as a chemical messenger in the immune system that regulates inflammation and attracts immune cells such as white blood cells.

How about the effect of IL8 on tumor? 06/01/2020

Regulating tumor microenvironment, promoting tumor growth and metastasis, and can be used in tumor therapy research.

What is the relationship between IL8 and inflammatory response? 01/18/2020

IL8 plays a role in regulating and promoting the migration and activation of inflammatory cells in the inflammatory response.

Which diseases can be treated with IL8? 12/02/2019

Can be used to treat inflammatory diseases (such as rheumatoid arthritis, psoriasis), tumors (such as lung cancer, breast cancer) and other diseases.

Is IL8 relevant to immunotherapy? 03/18/2019

Yes, IL8 is closely related to immunotherapy, which can enhance the role of the immune system and assist in the treatment of certain diseases.

By what method is IL8 generally prepared? 02/03/2019

IL8 is generally prepared by gene recombination technology, and the IL8 gene is introduced into the appropriate expression system, and then expressed and purified.

Customer Reviews (3)

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Reviews
10/28/2022

    IL8 has good fluorescence and absorption properties.

    11/29/2020

      NIPBL has good stability in different environments and is not easy to degrade.

      04/17/2019

        Through animal models or in vitro experiments to evaluate the mechanism of the recombinant protein in related diseases, we found that the effect is very good.

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