Active Native ADP-specific glucokinase
Cat.No. : | ADPGK-45 |
Product Overview : | Native ADP-specific glucokinase (EC 2.7.1.147) was purified from Pyrococcus furiosus. |
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- Gene Information
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Description : | In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reactionADP + D-glucose \rightleftharpoons AMP + D-glucose 6-phosphateThus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate. |
Source : | Pyrococcus furiosus |
Species : | Pyrococcus furiosus |
Form : | White lyophilized powder. |
Bio-activity : | ≥30 U/mg |
Storage : | Store in tightly closed containers, desiccated, protected from light, at -20oC. |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionCurrently, there is limited evidence to suggest that mutations in the ADPGK gene itself directly cause disease. However, some studies have identified single nucleotide polymorphisms (SNPs) in ADPGK that may be associated with increased risk of certain disease states, such as Alzheimer's disease and type 2 diabetes.
One of the main challenges in studying Adpgk is the lack of knowledge about its cellular functions and regulatory mechanisms. Additionally, because Adpgk is a relatively understudied gene, there is limited information available about its interactions with other proteins and cellular processes. More research is needed to fully understand the role of Adpgk in health and disease.
Researchers can study Adpgk in the laboratory using a variety of techniques, such as enzyme assays, western blotting, and immunohistochemistry. They may also use genetic and molecular biology tools to manipulate Adpgk expression or function in cells or animal models.
Yes, there is ongoing research on Adpgk in a variety of fields, including metabolism, immunology, and drug development. Scientists are working to better understand the function of Adpgk in these contexts and explore its potential as a therapeutic target.
There is growing interest in Adpgk as a potential drug target for metabolic disorders. Some studies have suggested that modulation of Adpgk activity could help regulate glucose metabolism, improve insulin sensitivity, and reduce the risk of metabolic diseases such as obesity and diabetes. However, further research is needed to fully explore the therapeutic potential of Adpgk in this context.
Adpgk is expressed in a variety of tissues throughout the body, with highest expression levels observed in the liver, muscle, and brain. It is also present in adipose tissue, kidney, heart, and pancreas, although to a lesser extent. The widespread expression of Adpgk suggests that it plays a role in multiple physiological processes and that dysregulation of its expression or activity could contribute to the development of various diseases.
Adpgk expression and activity are regulated by a variety of factors, including hormonal signals, nutrient availability, and oxidative stress. Insulin and glucagon are two key hormones that regulate Adpgk expression in response to changes in blood glucose levels. Nutrient availability also plays a role in Adpgk regulation, with high glucose levels leading to increased Adpgk expression. Furthermore, Adpgk activity can be modulated by post-translational modifications such as phosphorylation, acetylation, and ubiquitination. Finally, oxidative stress has been shown to downregulate Adpgk expression, possibly through the activation of stress-responsive pathways such as NF-κB.
Yes, Adpgk has been identified as a potential target for drug development in the treatment of metabolic disorders such as diabetes. Researchers are exploring the use of Adpgk activators or inhibitors to modulate glucose metabolism and improve glycemic control in patients with these conditions. However, further research is needed to determine the safety and efficacy of these approaches.
Adpgk can be studied in the laboratory using a variety of techniques, including molecular biology, biochemistry, and cell biology approaches. These may involve cloning and expressing Adpgk in bacterial or eukaryotic cells, purifying the protein to determine its structure and enzymatic activity, or using gene knockdown or overexpression techniques to investigate its function in cells or animal models. In addition, high-throughput screening methods such as chemical compound libraries can be used to identify small molecules that modulate Adpgk activity or expression.
Adpgk is involved in several cellular processes, including glucose metabolism, glycolysis, and glycogen synthesis. Its primary function is to catalyze the conversion of ADP-glucose (ADPG) to glucose-1-phosphate (G1P), which is an important step in glycogen synthesis. It also plays a role in regulating glucose metabolism and insulin signaling by modulating the levels of ADPG and G1P. In addition, Adpgk has been implicated in other processes such as DNA repair, lipid metabolism, and autophagy.
Yes, mutations in the Adpgk gene have been linked to several medical conditions, including glycogen storage disease type 0 and type 13. These conditions are characterized by a deficiency in Adpgk activity, which impairs the body's ability to synthesize glycogen and regulate blood glucose levels. Symptoms of these conditions may include hypoglycemia, muscle weakness, and fatigue.
There is some evidence to suggest that Adpgk levels may be altered in certain disease states, such as diabetes and liver disease. However, more research is needed to determine whether Adpgk could be used as a reliable biomarker for these conditions.
Currently, there are no drugs that specifically target Adpgk. However, some compounds have been identified that can modulate Adpgk activity or expression indirectly. For example, some studies have found that certain bioactive compounds, such as berberine and quercetin, can induce Adpgk expression in cells and potentially have therapeutic benefits.
Customer Reviews (4)
Write a reviewI highly recommend this protein and the manufacturer's services to anyone in need of high-quality research materials and excellent technical support.
I am very pleased with the excellent technical support provided by the manufacturer, which has been instrumental in solving some of my experimental problems.
The ADPGK protein that I have obtained for my experiments is of exceptional quality and meets my experimental needs perfectly.
Their prompt response and knowledge have been invaluable and have contributed significantly to the success of my research.
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