Recombinant Human TGFB3, Animal Free
Cat.No. : | TGFB3-126H |
Product Overview : | Recombinant human TGF-beta3 is a 27.2 kDa protein composed of two identical 118 amino acid polypeptide chains linked by a single disulphide bond. Human recombinant protein expressed in Nicotiana benthamiana. Recombinant human TGF-beta-3 contains a 6-His-tag at the N-terminal end, is produced by transient expression in non-transgenic plants and is purified by sequential chromatography (FPLC). This product contains no animal–derived components or impurities. Animal free product. |
- Specification
- Gene Information
- Related Products
Description : | Recombinant human TGF-beta3 is a 27.2 kDa protein composed of two identical 118 amino acid peptide chains linked by a single disulphide bond. Transforming growth factor–beta is a family of five related cytokines that have been shown on a wide variety of normal and neoplastic cells, indicating the importance of these homo-dimmer proteins as multi-functional regulators of cellular activity. The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2 and TGF-beta3) signal through the same receptor and elicit similar biological responses. They are involved in physiological processes as embryogenesis, tissue remodelling and wound healing. |
Source : | Nicotiana benthamiana |
Species : | Human |
Form : | Lyophilized from a Tris HCl 0.05M buffer at pH 7.4. |
Molecular Mass : | Recombinant human TGF-beta3 is a 27.2 kDa protein composed of two identical 118 amino acid polypeptide chains linked by a single disulphide bond. |
AA Sequence : | HHHHHHALDTNYCFRNLEENCCVRP LYIDFRQDLGWKWVHEPKGYYANFC SGPCPYLRSADTTHSTVLGLYNTLN PEASASPCCVPQDLEPLTILYYVGR TPKVEQLSNMVVKSCKCS |
Endotoxin : | < 0.04 eu ug protein (lal> |
Purity : | >97% by SDS-PAGE gel |
Applications : | Western blot, Immunogen |
Storage : | This lyophilized preparation is stable at 2-8o C for short term, long storage it should be kept at -20oC. Reconstituted protein should be stored in working aliquots at –20°C and it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended. |
Reconstitution : | Lyophilized protein should be reconstituted in water to a concentration of 25-50 ng / ul. Due to the protein nature, dimmers and multimers may be observed. Upon reconstitution, It can be stored in working aliquots at –20°C for future use. Optimal reconstitution please follow batch Quality Control sheet instructions. |
Gene Name : | TGFB3 transforming growth factor, beta 3 [ Homo sapiens ] |
Official Symbol : | TGFB3 |
Synonyms : | TGFB3; transforming growth factor, beta 3; transforming growth factor beta-3; TGF-beta-3; ARVD; TGF-beta3; FLJ16571; |
Gene ID : | 7043 |
mRNA Refseq : | NM_003239 |
Protein Refseq : | NP_003230 |
MIM : | 190230 |
UniProt ID : | P10600 |
Chromosome Location : | 14q24 |
Pathway : | ALK1 signaling events, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; |
Function : | growth factor activity; identical protein binding; protein binding; contributes_to protein binding; protein heterodimerization activity; transforming growth factor beta binding; transforming growth factor beta receptor binding; type I transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding; |
Products Types
◆ Recombinant Protein | ||
TGFB3-105H | Active Recombinant Human TGFB3 Protein | +Inquiry |
Tgfb3-2129M | Recombinant Mouse Tgfb3 Protein, His-tagged | +Inquiry |
TGFB3-247H | Active Recombinant Human/Mouse TGFB3 Protein | +Inquiry |
TGFB3-4502R | Recombinant Rhesus Macaque TGFB3 Protein, His (Fc)-Avi-tagged | +Inquiry |
TGFB3-248H | Active Recombinant Human/Mouse TGFB3 Protein | +Inquiry |
◆ Lysates | ||
TGFB3-1118HCL | Recombinant Human TGFB3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionCurrently, researchers are exploring treatments that target TGFB3. Several drugs and antibodies have shown potential efficacy against TGFB3 and are being used in clinical trials for the treatment of the disease.
TGFB3 can regulate cell proliferation by activating multiple signaling pathways, such as the Smad signaling pathway and non-Smad signaling pathway. It can promote the progression of the cell cycle or inhibit cell proliferation, depending on the cell type and context.
TGFB3 protein can be used as a biomarker to assist the clinical diagnosis of a variety of diseases, such as congenital developmental abnormalities, inflammatory diseases and fibrotic diseases. Measuring TGFB3 protein levels can provide an indicator of early diagnosis and prognostic assessment of disease.
Mutations in TGFB3 have been found to be associated with inherited connective tissue diseases such as Loeys-Dietz syndrome and Marfan syndrome.
In pulmonary fibrosis, the expression of TGFB3 is elevated and is involved in the development of pulmonary fibrosis. Due to its important role in the pathological process, inhibition of the TGFB3 signaling pathway may be a potential strategy for the treatment of pulmonary fibrosis.
TGFB3 plays an important regulatory role in the immune system. It can influence the immune response through the proliferation, differentiation, and functional regulation of immune cells.
Customer Reviews (3)
Write a reviewReproducibility is very good, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of reproducibility.
Their recombinant proteins are very soluble and can be easily dissolved in various buffers.
Catalytic activity of this protein is very high, which can greatly reduce the time and energy required for chemical reactions and has high economic value.
Ask a Question for All TGFB3 Products
Required fields are marked with *
My Review for All TGFB3 Products
Required fields are marked with *
Inquiry Basket