Active Native Mouse Thrombin

• Cat.No.: Thrombin-31M
• Product Overview: Native Mouse Thrombin was purified from Plasma.

Specification

• Description: Thrombin (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease that in humans is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the reduction of blood loss. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.
• Source: Plasma
• Species: Mouse
• Form: 50% glycerol/water (v/v)
• Bio-activity: approximately 3800 NIH units/mg
• Molecular Mass: 36700 Da
• Purity: >95% by SDS-PAGE
• Storage: Glyercol formulation: -20°CHepes formulation: -80°C
• Publication:
  A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice (2023)

Gene Information

• Gene Name: F2 coagulation factor II [ Mus musculus ]
• Official Symbol: F2
• Synonyms: F2; coagulation factor II; prothrombin; Cf2; FII; Cf-2; thrombin
• Gene ID: 14061
• mRNA Refseq: NM_010168
• Protein Refseq: NP_034298
• Pathway: Blood Clotting Cascade, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem
• Function: calcium ion binding; catalytic activity; hydrolase activity; peptidase activity; protein binding; receptor binding; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; thrombospondin receptor activity