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Recombinant human TGFB3, Active

Cat.No. : TGFB3-1571H
Product Overview : Recombinant human TGF-beta3 is a 27.2 kDa protein composed of two identical 118 amino acid polypeptide chains linked by a single disulphide bond.
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Description : Recombinant human TGF-beta3 is a 27.2 kDa protein composed of two identical 118 amino acid peptide chains linked by a single disulphide bond. Transforming growth factor–beta is a family of five related cytokines that have been shown on a wide variety of normal and neoplastic cells, indicating the importance of these homo-dimmer proteins as multi-functional regulators of cellular activity. The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2 and TGF-beta3) signal through the same receptor and elicit similar biological responses. They are involved in physiological processes as embryogenesis, tissue remodeling and wound healing.
Source : Human recombinant protein expressed in Nicotiana benthamiana. It is produced by transient expression in non-transgenic plants. This product contains no animal–derived components or impurities. Animal Free product.
Species : Human
Form : Recombinant human TGF beta-3 is lyophilized from a Tris HCl 0.05M buffer at pH 7.4.
Molecular Mass : 27.2 kDa
AA Sequence : HHHHHHALDTNYCFRNLEENCCVRP LYIDFRQDLGWKWVHEPKGYYANFC SGPCPYLRSADTTHSTVLGLYNTLN PEASASPCCVPQDLEPLTILYYVGR TPKVEQLSNMVVKSCKCS
Endotoxin : < 0.04 eu/μg protein (lal>
Purity : >97% by SDS-PAGE gel
Storage : This lyophilized preparation is stable at 2-8o C for short term, long storage it should be kept at -20oC. Reconstituted protein should be stored in working aliquots at –20°C. Repeated freezing and thawing is not recommended.
Reconstitution : Centrifuge vial before opening. Lyophilized protein should be reconstituted in water to a concentration of 25-50 ng/μl. Due to the protein nature, dimmers and multimers may be observed. At higher concentration the solubility may be reduced and multimers generated. Optimal concentration should be determined for specific application and cell lines.
Gene Name : TGFB3 transforming growth factor, beta 3 [ Homo sapiens ]
Official Symbol : TGFB3
Synonyms : TGFB3; transforming growth factor, beta 3; transforming growth factor beta-3; TGF-beta-3; ARVD; TGF-beta3; FLJ16571;
Gene ID : 7043
mRNA Refseq : NM_003239
Protein Refseq : NP_003230
MIM : 190230
UniProt ID : P10600
Chromosome Location : 14q24
Pathway : ALK1 signaling events, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem;
Function : growth factor activity; identical protein binding; protein binding; contributes_to protein binding; protein heterodimerization activity; transforming growth factor beta binding; transforming growth factor beta receptor binding; type I transforming growth

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a treatment for TGFB3? 12/16/2019

Currently, researchers are exploring treatments that target TGFB3. Several drugs and antibodies have shown potential efficacy against TGFB3 and are being used in clinical trials for the treatment of the disease.

How does TGFB3 participate in cell proliferation? 08/27/2019

TGFB3 can regulate cell proliferation by activating multiple signaling pathways, such as the Smad signaling pathway and non-Smad signaling pathway. It can promote the progression of the cell cycle or inhibit cell proliferation, depending on the cell type and context.

What are the applications of TGFB3 protein in clinical diagnosis? 07/25/2019

TGFB3 protein can be used as a biomarker to assist the clinical diagnosis of a variety of diseases, such as congenital developmental abnormalities, inflammatory diseases and fibrotic diseases. Measuring TGFB3 protein levels can provide an indicator of early diagnosis and prognostic assessment of disease.

Are there any genetic diseases associated with TGFB3? 06/23/2019

Mutations in TGFB3 have been found to be associated with inherited connective tissue diseases such as Loeys-Dietz syndrome and Marfan syndrome.

Is TGFB3 potentially used to treat pulmonary fibrosis? 05/25/2019

In pulmonary fibrosis, the expression of TGFB3 is elevated and is involved in the development of pulmonary fibrosis. Due to its important role in the pathological process, inhibition of the TGFB3 signaling pathway may be a potential strategy for the treatment of pulmonary fibrosis.

How is TGFB3 related to the immune system? 04/13/2019

TGFB3 plays an important regulatory role in the immune system. It can influence the immune response through the proliferation, differentiation, and functional regulation of immune cells.

Customer Reviews (3)

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Reviews
12/08/2019

    Reproducibility is very good, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of reproducibility.

    10/13/2019

      Their recombinant proteins are very soluble and can be easily dissolved in various buffers.

      05/19/2019

        Catalytic activity of this protein is very high, which can greatly reduce the time and energy required for chemical reactions and has high economic value.

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