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Active Recombinant Human FOLH1, His-tagged

Cat.No. : FOLH1-2415H
Product Overview : Recombinant Human FOLH1(Lys44-Ala750), fused with an N-terminal 6-His tag, was expressed in CHO Cells.
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Description : This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
Source : CHO Cells
Species : Human
Tag : His
Predicted N Terminal : His
Form : Supplied as a 0.2 µm filtered solution in MES and NaCl.
Bio-activity : Measured by its ability to hydrolyze the substrate N-acetyl-L-Asp-L-Glu into N-acetyl-L-Asp and L-Glu. The L-Glu product is measured by fluorescence after its derivatization by ortho-phthaldialdehyde. The specific activity is >400 pmol/min/µg.
Molecular Mass : Predicted Molecular Mass: 80 kDaSDS-PAGE: 110 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.6 months from date of receipt, -20 to -70 °C as supplied.3 months, -20 to -70 °C under sterile conditions after opening.
Gene Name : FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 [ Homo sapiens (human) ]
Official Symbol : FOLH1
Synonyms : FOLH1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; folate hydrolase (prostate-specific membrane antigen) 1; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; NP_001014986.1; EC 3.4.17.21; NP_001180400.1; NP_001180401.1; NP_001180402.1; NP_004467.1
Gene ID : 2346
mRNA Refseq : NM_001014986
Protein Refseq : NP_001014986
MIM : 600934
UniProt ID : Q04609
Chromosome Location : 11p11.2
Pathway : One Carbon Metabolism; Vitamin digestion and absorption
Function : carboxypeptidase activity; dipeptidase activity; metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What advancements have been made in FOLH1-targeted therapies recently? 03/16/2021

New radioligands and imaging agents with enhanced specificity and reduced off-target effects are being developed for more effective treatment.

How does targeting FOLH1 impact treatment precision? 01/27/2021

Targeting FOLH1 helps deliver treatments directly to cancer cells, minimizing damage to healthy tissues, thus improving treatment precision.

Are there other potential applications of FOLH1 beyond prostate cancer? 03/16/2018

Yes, research suggests potential roles in imaging and therapy for other cancers expressing FOLH1, such as renal cell carcinoma and certain types of gliomas.

Can FOLH1 be used for early cancer detection? 11/19/2017

Yes, FOLH1-based imaging techniques show promise in detecting cancer at early stages, aiding in timely intervention and improved outcomes.

Are there ongoing clinical trials exploring FOLH1's applications? 03/25/2016

Yes, numerous trials investigate FOLH1-targeted imaging and therapies in various cancers, aiming to expand its clinical utility.

Customer Reviews (3)

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Reviews
09/05/2019

    It has been shown to play a crucial role in multiple cellular processes, making it highly valuable for investigations into cell signaling, inflammation, and immune responses.

    01/28/2018

      Incorporating the FOLH1 protein into your research will not only meet but exceed your expectations, enabling you to advance your scientific discoveries with confidence.

      06/06/2016

        Researchers can leverage the unique properties of the FOLH1 protein to gain insights into its biological functions and its impact on disease mechanisms.

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