Recombinant Human ESR1, StrepII-tagged
Cat.No. : | ESR1-227H |
Product Overview : | Purified human recombinant Estrogen receptor or ER protein (amino acids 2-181, 180 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 19.4 kDa. (Accession NP_000116.2; UniProt P03372) |
- Specification
- Gene Information
- Related Products
Description : | This product is the N-terminal region of estrogen receptor. ER is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
Protein length : | 2-181, 180 a.a. |
AA Sequence : | TMTLHTKASGMALLHQIQGNELEPL NRPQLKIPLERPLGEVYLDSSKPAV YNYPEGAAYEFNAAAAANAQVYGQT GLPYGPGSEAAAFGSNGLGGFPPLN SVSPSPLMLLHPPPQLSPFLQPHGQ QVPYYLENEPSGYTVREAGPPAFYR PNSDNRRQGGRERLASTNDKGSMAM ESAKE |
Endotoxin : | <0.1 eu per ug protein by lal |
Purity : | >95% pure by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
Gene Name : | ESR1 estrogen receptor 1 [ Homo sapiens ] |
Official Symbol : | ESR1 |
Synonyms : | ESR1; estrogen receptor 1; ESR; estrogen receptor; Era; NR3A1; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen receptor alpha 3*,4,5,6,7*/822 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform; ER; ESRA; DKFZp686N23123; |
Gene ID : | 2099 |
mRNA Refseq : | NM_000125 |
Protein Refseq : | NP_000116 |
UniProt ID : | P03372 |
Chromosome Location : | 6q24-q27 |
Pathway : | Androgen Receptor Signaling Pathway, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; Estrogen signaling pathway, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; FOXM1 transcription factor network, organism-specific biosystem; Gene Expression, organism-specific biosystem; |
Function : | DNA binding; beta-catenin binding; chromatin binding; core promoter sequence-specific DNA binding; enzyme binding; enzyme binding; estrogen receptor activity; estrogen receptor activity; estrogen response element binding; hormone binding; identical protein binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; nitric-oxide synthase regulator activity; protein binding; protein complex binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; steroid binding; steroid hormone receptor activity; steroid hormone receptor activity; transcription factor binding; type 1 metabotropic glutamate receptor binding; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
ESR1-1808R | Recombinant Rat ESR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ESR1-3504H | Recombinant Human ESR1 Protein, GST-tagged | +Inquiry |
ESR1-02H | Recombinant Human ESR1 Protein, His-tagged | +Inquiry |
ESR1-2534H | Recombinant Human ESR1 protein(191-270 aa), C-His-tagged | +Inquiry |
ESR1-1390H | Recombinant Human ESR1 Protein (10-595 aa), His-tagged | +Inquiry |
◆ Lysates | ||
ESR1-6540HCL | Recombinant Human ESR1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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