Recombinant Human ISG15, StrepII-tagged
Cat.No. : | ISG15-258H |
Product Overview : | Purified, full-length human recombinant ISG15 or Ubiquitin-like protein (amino acids 2-157, 156 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 17 kDa. (Accession NP_005092.1; UniProt P05161) |
- Specification
- Gene Information
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Description : | ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. |
Source : | Human Cells |
Species : | Human |
Tag : | StrepII |
Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
Protein length : | 2-157, 156 a.a. |
AA Sequence : | GWDLTVKMLAGNEFQVSLSSSMSVS ELKAQITQKIGVHAFQQRLAVHPSG VALQDRVPLASQGLGPGSTVLLVVD KCDEPLSILVRNNKG |
Endotoxin : | <0.1 eu per ug protein by lal |
Purity : | >95% pure by SDS-PAGE |
Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
Gene Name : | ISG15 ISG15 ubiquitin-like modifier [ Homo sapiens ] |
Official Symbol : | ISG15 |
Synonyms : | ISG15; ISG15 ubiquitin-like modifier; G1P2, interferon, alpha inducible protein (clone IFI 15K); ubiquitin-like protein ISG15; IFI15; UCRP; ubiquitin cross-reactive protein; interferon-induced 15 kDa protein; interferon-induced 17 kDa protein; interferon-stimulated protein, 15 kDa; interferon-induced 17-kDa/15-kDa protein; interferon, alpha-inducible protein (clone IFI-15K); G1P2; IP17; hUCRP; |
Gene ID : | 9636 |
mRNA Refseq : | NM_005101 |
Protein Refseq : | NP_005092 |
MIM : | 147571 |
UniProt ID : | P05161 |
Chromosome Location : | 1p36.33 |
Pathway : | Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; ISG15 antiviral mechanism, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; Interferon alpha/beta signaling, organism-specific biosystem; |
Function : | protein tag; |
Products Types
◆ Recombinant Protein | ||
ISG15-12H | Recombinant Human ISG15 Protein (2-157), Rhodamine 110 Labeled | +Inquiry |
ISG15-1203H | Recombinant Human ISG15 Protein, His (Fc)-Avi-tagged | +Inquiry |
ISG15-2127R | Recombinant Rhesus Macaque ISG15 Protein, His (Fc)-Avi-tagged | +Inquiry |
ISG15-191H | Recombinant Human ISG15 protein(Met1-Gly157) | +Inquiry |
ISG15-4606H | Recombinant Human ISG15 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ISG15-5152HCL | Recombinant Human ISG15 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionISG15 has been investigated as a potential therapeutic target for developing antiviral drugs.
Scientists are exploring ISG15-related pathways as potential therapeutic targets for neurodegenerative disease treatment.
ISG15 is used as a biomarker to monitor and diagnose viral infections, such as influenza, HIV, and SARS-CoV-2.
Dysregulation of ISG15 has been linked to autoimmune diseases like systemic lupus erythematosus (SLE).
Yes, elevated levels of ISG15 in the blood can indicate a more severe viral infection.
Customer Reviews (3)
Write a reviewThe manufacturer's support has played a vital role in my work, providing expert guidance and troubleshooting assistance whenever needed.
It has been extensively utilized in protein electron microscopy structure analysis, yielding exceptional outcomes.
I am grateful for their dedication and commitment to ensuring the success of my experiments.
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