Recombinant Human MTOR, MYC/DDK-tagged

• Cat.No.: MTOR-156H
• Product Overview: Recombinant Human MTOR, fused with C-terminal MYC/DDK, was expressed in HEK293.

Specification

• Description: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 288.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens (human) ]
• Official Symbol: MTOR
• Synonyms: MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mechanistic target of rapamycin (serine/threonine kinase); serine/threonine-protein kinase mTOR; rapamycin target protein 1; mammalian target of rapamycin; rapamycin and FKBP12 target 1; FKBP-rapamycin associated protein; rapamycin associated protein FRAP2; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; NP_004949.1; EC 2.7.1.1; EC 2.7.11.1
• Gene ID: 2475
• mRNA Refseq: NM_004958
• Protein Refseq: NP_004949
• MIM: 601231
• UniProt ID: P42345
• Chromosome Location: 1p36.2
• Pathway: Acute myeloid leukemia; Alpha6-Beta4 Integrin Signaling Pathway; Class I PI3K signaling events mediated by Akt
• Function: ATP binding; RNA polymerase III type 1 promoter DNA binding; TFIIIC-class transcription factor binding