Recombinant Human ALK (F1174L), GST-tagged
Cat.No. : | ALK-28H |
Product Overview : | Recombinant human ALK (F1174L) (1060-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | ALK or anaplastic lymphoma kinase is a receptor tyrosine kinase that was originally identified as a member of the insulin receptor subfamily that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types. In the nervous system, ALK in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, ALK expression can lead to developmental neuronal apoptosis. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~90 kDa |
Applications : | Kinase Assay |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | ALK anaplastic lymphoma receptor tyrosine kinase [ Homo sapiens ] |
Official Symbol : | ALK |
Synonyms : | ALK; anaplastic lymphoma receptor tyrosine kinase; anaplastic lymphoma kinase (Ki 1); ALK tyrosine kinase receptor; CD246; CD246 antigen; mutant anaplastic lymphoma kinase; NBLST3; |
Gene ID : | 238 |
mRNA Refseq : | NM_004304 |
Protein Refseq : | NP_004295 |
MIM : | 105590 |
UniProt ID : | Q9UM73 |
Chromosome Location : | 2p23 |
Function : | ATP binding; NF-kappaB-inducing kinase activity; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (17)
Ask a questionThe common mutation of ALK and other genes may affect the prognosis and therapeutic effect of lung cancer, and provide new ideas for individualized treatment.
Phosphorylation of ALK can affect its activity and signal transmission efficiency, which has an impact on the biological process of cells.
The application prospect of ALK in the treatment of breast cancer needs to be further studied and discussed, and the expression level in breast cancer cells is not clear.
The interaction between ALK and other tumor suppressor genes may affect the occurrence and development of tumors, and provide new ideas for tumor treatment.
This is involved in a variety of lung cancer signaling pathways, such as PI3K/Akt, MAPK/ERK, STAT3 and other pathways.
It is associated with lung cancer, thyroid cancer, lymphoma and neuroblastoma.
As a targeted drug, ALK is mainly used by oral administration and intravenous injection, which can help in the treatment of diseases such as lung cancer.
ALK is overexpressed in a small number of lung cancer patients and is involved in the occurrence and development of lung cancer.
The mutation may affect the prognosis and therapeutic effect of lung cancer, suggesting the importance of ALK targeted therapy.
ALK is involved in signal transduction and cell growth in nervous system tumors, and has a certain influence on the occurrence and development of nervous system tumors.
ALK plays an important role in many physiological processes such as neuron migration, embryonic development and osteoblast differentiation.
ALK can be used as one of the screening indicators for lung cancer, which can help the early diagnosis and treatment of lung cancer.
ALK is expressed in a variety of cell types such as the nervous system, lymphatic system, and immune system, and is involved in a variety of biological processes.
The regulatory mechanisms of ALK mainly include gene mutation, gene expression regulation, quality control and signal pathway regulation.
The effect of ALK targeted therapy on the prognosis of lung cancer may be related to a variety of factors, including tumor stage, pathological type, treatment regimen, etc.
ALK can be used as an important marker of targeted therapy in the treatment of lung cancer, providing an individualized treatment strategy.
The relationship between ALK and colorectal cancer is unclear and needs further study.
Customer Reviews (4)
Write a reviewALK has strict quality control and complies with relevant industry standards.
The yield of ALK is high and has good economic benefits.
The enzymatic activity of ALK reached the expected level and was able to play a role in specific reactions.
Stable and reproducible results can be obtained when experiments are performed using ALK.
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