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Recombinant Human nicotinamide nucleotide adenylyltransferase 2, His-tagged

Cat.No. : NMNAT2-300H
Product Overview : NMNAT2, 1-307 aa, Human, His tag, E.coli
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  • Gene Information
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Description : NMNAT2 belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. Recombinant human NMNAT2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT
Molecular Mass : 36.6 kDa (327aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MTETTKTHVI LLACGSFNPI TKGHIQMFER ARDYLHKTGR FIVIGGIVSP VHDSYGKQGL VSSRHRLIMC QLAVQNSDWI RVDPWECYQD TWQTTCSVLE HHRDLMKRVT GCILSNVNTP SMTPVIGQPQ NETPQPIYQN SNVATKPTAA KILGKVGESL SRICCVRPPV ERFTFVDENA NLGTVMRYEE IELRILLLCG SDLLESFCIP GLWNEADMEV IVGDFGIVVV PRDAADTDRI MNHSSILRKY KNNIMVVKDD INHPMSVVSS TKSRLALQHG DGHVVDYLSQ PVIDYILKSQ LYINASG
Purity : >85% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 0.25mg/ml (determined by Bradford assay)
Gene Name : NMNAT2 nicotinamide nucleotide adenylyltransferase 2 [ Homo sapiens ]
Official Symbol : NMNAT2
Synonyms : NMNAT2; nicotinamide nucleotide adenylyltransferase 2; C1orf15, chromosome 1 open reading frame 15; nicotinamide mononucleotide adenylyltransferase 2; KIAA0479; PNAT2; NMN adenylyltransferase 2; NaMN adenylyltransferase 2; pyridine nucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 2; C1orf15; MGC2756;
Gene ID : 23057
mRNA Refseq : NM_015039
Protein Refseq : NP_055854
MIM : 608701
UniProt ID : Q9BZQ4
Chromosome Location : 1q25
Pathway : Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; NAD biosynthesis II (from tryptophan), organism-specific biosystem; NAD biosynthesis III, organism-specific biosystem; NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, organism-specific biosystem;
Function : ATP binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; nucleotide binding; nucleotidyltransferase activity; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does NMNAT2 relate to other proteins involved in neuroprotection? 09/13/2022

NMNAT2 is part of a network of proteins involved in neuroprotection, and understanding these interactions may provide insights into potential therapeutic strategies.

Are there any ongoing clinical trials related to NMNAT2? 11/17/2020

It's essential to check the latest clinical trial databases for updated information, as ongoing trials may be exploring the therapeutic potential of NMNAT2.

Are there any specific neurodegenerative diseases linked to NMNAT2 dysfunction? 09/19/2017

Some studies suggest a connection between NMNAT2 and conditions like Alzheimer's disease, making it a potential target for therapeutic interventions.

How can the clinical application of NMNAT2 impact aging? 10/03/2016

As NMNAT2 is associated with NAD+ production, its clinical application may have implications for addressing age-related decline in cellular function and overall health.

Can dietary interventions impact NMNAT2 levels? 01/02/2016

Some studies suggest that certain dietary interventions, such as those affecting NAD+ levels, may indirectly influence NMNAT2 activity.

Customer Reviews (3)

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Reviews
04/17/2019

    It reliably and accurately detects and quantifies target molecules, allowing for precise measurement of analytes in my samples.

    11/25/2018

      The NMNAT2 Protein consistently produces well-defined and interpretable structural data, enabling me to unravel complex macromolecular assemblies and their mechanisms.

      01/28/2017

        The sensitivity and specificity of the NMNAT2 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.

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