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Recombinant Human matrix metallopeptidase 8 (neutrophil collagenase), His-tagged

Cat.No. : MMP8-446H
Product Overview : MMP8, 101- 467aa, Human, His tag, E.coli
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  • Gene Information
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Description : MMP8 protein of the matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP"s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. MMP8 is part of a cluster of MMP. Recombinant human MMP8 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
Molecular Mass : 44.3 kDa (390aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSLTPGNPK WERTNLTYRI RNYTPQLSEA EVERAIKDAF ELWSVASPLI FTRISQGEAD INIAFYQRDH GDNSPFDGPN GILAHAFQPG QGIGGDAHFD AEETWTNTSA NYNLFLVAAH EFGHSLGLAH SSDPGALMYP NYAFRETSNY SLPQDDIDGI QAIYGLSSNP IQPTGPSTPK PCDPSLTFDA ITTLRGEILF FKDRYFWRRH PQLQRVEMNF ISLFWPSLPT GIQAAYEDFD RDLIFLFKGN QYWALSGYDI LQGYPKDISN YGFPSSVQAI DAAVFYRSKT YFFVNDQFWR YDNQRQFMEP GYPKSISGAF PGIESKVDAV FQQEHFFHVF SGPRYYAFDL IAQRVTRVAR GNKWLNCRYG
Purity : >85% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Bradford assay)
Gene Name : MMP8 matrix metallopeptidase 8 (neutrophil collagenase) [ Homo sapiens ]
Official Symbol : MMP8
Synonyms : MMP8; matrix metallopeptidase 8 (neutrophil collagenase); CLG1, matrix metalloproteinase 8 (neutrophil collagenase); neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL;
Gene ID : 4317
mRNA Refseq : NM_002424
Protein Refseq : NP_002415
MIM : 120355
UniProt ID : P22894
Chromosome Location : 11q21-q22
Pathway : Activation of Matrix Metalloproteinases, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem;
Function : calcium ion binding; metalloendopeptidase activity; peptidase activity; serine-type endopeptidase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What signaling pathways does the MMP8 protein interact with? 11/16/2019

The MMP8 protein interacts with a variety of signaling pathways, including TNF-α, TGF-β, Wnt, and NF-κB.

What drugs interact with the MMP8 protein? 08/14/2019

A number of inhibitors and modulators of MMP8 protein have been developed for the regulation of MMP8 activity and the treatment of related diseases.

Why does MMP8 protein play a role in tissue repair? 04/18/2019

The MMP8 protein is involved in the tissue repair and wound healing process, by degrading damaged tissue and supporting the formation of new tissue.

What is the mechanism of action of MMP8 protein in inflammatory response? 03/08/2019

MMP8 protein is involved in regulating the production of inflammation-related molecules and cell infiltration, promoting the occurrence and maintenance of inflammatory response.

Does MMP8 have a role in post-traumatic recovery? 03/04/2019

MMP8 protein is involved in the inflammatory and remodeling processes of post-traumatic wound healing, contributing to wound repair and tissue regeneration.

Does the MMP8 protein study have implications for new drug development? 01/13/2019

MMP8 protein plays an important role in the occurrence and progression of diseases, and studying the regulatory mechanism of MMP8 protein is helpful for the development of new drugs, such as inhibitors targeting MMP8 protein may be applied to the treatment of related diseases

Customer Reviews (3)

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Reviews
04/03/2022

    The use of MMP8 as a catalyst can significantly increase the rate and yield of chemical reactions with impressive high catalytic efficiency.

    09/14/2021

      MMP8 is really impressive, the results of every experiment are very consistent, you can see that its production process is very careful.

      03/20/2021

        MMP8 are inexpensive to prepare and cost-effective, making them ideal for our study.

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