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Recombinant Human FCGR2A, His & AVI Tagged, Biotinylated, 167 Arg

Cat.No. : FCGR2A-2964H
Product Overview : A DNA sequence encoding the extracellular domain (Met 1-Met 210) of human CD32a (AAA35827.1) was fused with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
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Description : Human CD32 class is encoded by three closely related genes, and designated Fcγ RII A, B, and C which share 94 - 99% amino acid identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. Fcγ RII A is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non- hematopoietic origin. Associated with an ITAM (immunoreceptor tyrosine-based activation motif)- bearing adapter subunit, Fc Rγ, CD32a (Fcγ RII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
Source : Human Cells
Species : Human
Tag : His & AVI Tag
Form : Lyophilized from sterile PBS , pH 7.4
Molecular Mass : The recombinant human CD32a consists of 213 amino acids after removal of the signal peptide and predicts a molecular mass of 23.6 kDa. It migrates as an approximately 32 kDa protein due to glycosylation by SDS-PAGE under reducing conditions.
Protein length : Met1-Met210
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >97 % as determined by SDS-PAGE
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Reconstitute with water to desired concentration.
Gene Name : FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) [ Homo sapiens ]
Official Symbol : FCGR2A
Synonyms : FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIa, receptor for (CD32) , FCG2, FCGR2, FCGR2A1; low affinity immunoglobulin gamma Fc region receptor II-a; CD32; CD32A; CDw32; IGFR2; Immunoglobulin G Fc receptor II; fcRII-a; fc-gamma-RIIa; fc-gamma RII-a; igG Fc receptor II-a; FCG2; FcGR; FCGR2; FCGR2A1; MGC23887; MGC30032;
Gene ID : 2212
mRNA Refseq : NM_001136219
Protein Refseq : NP_001129691
MIM : 146790
UniProt ID : P12318
Chromosome Location : 1q23
Pathway : Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Leishmaniasis, organism-specific biosystem; Leishmaniasis, conserved biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem; Phagosome, organism-specific biosystem;
Function : IgG binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does FCGR2A impact the risk and severity of certain allergic reactions? 03/22/2023

FCGR2A may influence the risk and severity of allergic reactions by modulating the immune response to allergens and antibodies involved in allergic processes.

In the context of infectious diseases, how does FCGR2A contribute to host defense mechanisms? 11/02/2022

FCGR2A participates in host defense against infectious diseases by facilitating the recognition and clearance of pathogens through antibody-mediated immune responses.

How does FCGR2A contribute to the understanding of immunogenetics? 05/26/2021

FCGR2A contributes to the understanding of immunogenetics by highlighting the genetic factors that influence immune responses and the development of immune-related diseases.

How can genetic variations in FCGR2A impact an individual's response to immunotherapy? 03/10/2020

Genetic variations in FCGR2A can influence an individual's response to immunotherapy by affecting the affinity of FCGR2A for antibodies, thereby modulating immune cell activation.

In what ways can FCGR2A be targeted for therapeutic interventions? 12/11/2017

FCGR2A can be targeted for therapeutic interventions through the development of drugs that modulate its activity, offering potential strategies for treating immune-related disorders.

Customer Reviews (3)

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Reviews
03/22/2023

    With its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.

    02/26/2023

      Its versatility allows for exploration of its extensive involvement in various biochemical and biological processes, providing valuable insights into its role and implications.

      07/24/2017

        The FCGR2A Protein demonstrates remarkable stability and functional efficiency, making it an indispensable tool for diverse scientific applications.

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