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Recombinant Canine ACVR1, Fc-tagged

Cat.No. : ACVR1-160C
Product Overview : A DNA sequence encoding the canine ACVR1 (XP_549615.2) (Met1-Glu123) was expressed with the Fc region of human IgG1 at the C-terminus.
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  • Gene Information
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Description : Cytokines and hormones belonging to the transforming growth factor beta (TGFβ) superfamily such as the activin, anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal, are involved in a variety of physiological processes including growth, cell differentiation, homeostasis, osteogenesis, and apoptosis. They initiate signaling through heteromeric complexes of a type I and a type I I serine/threonine kinase receptor. The two type receptors are type I transmembrane proteins and are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found in the type I receptors. Type II receptors are required for binding ligands and recruitment of type I receptors which then form stable complexes, and type I receptors are essential for signaling transduction. ALK2, also termed as ACVR1, ActRI, SKR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or IIB. In addition, ALK2 is also identified as a BMP type I receptor. ACVR1 has been demonstrated to form complex with either the BMP-2/7-bound BMPR-II or ACVR2A/ACVR2B and transduce signals to downstream components R-SMADs. Recombinant soluble ALK2 does not bind activin. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Source : Human Cells
Species : Canine
Tag : Fc
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant canine ACVR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 344 amino acids and has a predicted molecular mass of 38.6 kDa. The apparent molecular mass of the protein is approximately 68 and 44 kDa in SDS-PAGE under reducing conditions.
Protein length : Met1-Glu123
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : (32.9+66.0) % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : ACVR1 activin A receptor, type I [ Canis lupus familiaris ]
Official Symbol : ACVR1
Synonyms : ACVR1; activin A receptor, type I; activin receptor type-1;
Gene ID : 478757
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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