Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human APCDD1, Fc-tagged

Cat.No. : APCDD1-223H
Product Overview : A DNA sequence encoding the human APCDD1 (NP_694545.1) (Met1-Gly486) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Specification
  • Gene Information
  • Related Products
Source : Human Cells
Species : Human
Tag : Fc
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant human APCDD1/Fc comprises 701 amino acids and has a predicted molecular mass 79.6 kDa. The apparent molecular mass of the protein is approximately 85.7 kDa in SDS-PAGE under reducing conditions.
Protein length : Met1-Gly486
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >85 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : APCDD1 adenomatosis polyposis coli down-regulated 1 [ Homo sapiens ]
Official Symbol : APCDD1
Synonyms : APCDD1; adenomatosis polyposis coli down-regulated 1; protein APCDD1; B7323; hypoptrichosis simplex; adenomatosis polyposis coli down-regulated 1 protein; HHS; HTS; DRAPC1; FP7019;
Gene ID : 147495
mRNA Refseq : NM_153000
Protein Refseq : NP_694545
MIM : 607479
UniProt ID : Q8J025
Chromosome Location : 18p11.21
Function : Wnt-protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (20)

Ask a question
What is the relationship between APCDD1 protein and pneumonia tuberculosis? 12/18/2022

APCDD1 protein has not been shown to have a direct relationship with pneumonia-tuberculosis.

Is APCDD1 protein involved in immune response? 08/25/2022

No clear relationship between APCDD1 protein and immune response has been found.

Is APCDD1 protein associated with liver cancer? 05/29/2022

Studies have shown that the expression level of APCDD1 gene in liver cancer tissues is significantly decreased, and its deletion may be closely related to the occurrence and development of liver cancer.

What is the role of APCDD1 protein in hepatitis? 04/15/2022

The role of APCDD1 protein in hepatitis is not yet clear, but it may be related to hepatocyte dysfunction and apoptosis.

What are the structural characteristics of APCDD1 protein? 04/05/2022

The APCDD1 protein is a member of the Wnt inhibitor family and mainly consists of an N-terminal signaling peptide and a C-terminal maturation peptide. The C-terminal peptide chain is mainly composed of multiple interlaced cysteine residues, forming a special domain.

What is the role of APCDD1 protein in RNA splicing? 01/29/2022

The mechanism of action of APCDD1 protein is independent of the RNA splicing process.

What is the role of APCDD1 protein in cardiovascular disease? 12/12/2021

APCDD1 protein may be involved in cardiomyocyte apoptosis, vascular endothelial cell proliferation and other processes in cardiovascular diseases.

Can APCDD1 protein be used as a molecule for targeted therapy? 09/04/2021

The mechanism of action of APCDD1 protein makes it a potential targeted therapeutic molecule, but the relevant clinical studies are currently lacking.

Do polymorphism of APCDD1 protein affect its function? 08/06/2021

The polymorphism of APCDD1 protein may affect its structure and function, but the exact extent of the impact needs more research.

Is there a relationship between APCDD1 protein and calcium ion regulation in vivo? 07/25/2021

The APCDD1 protein has not been shown to have a clear relationship with calcium ion regulation in the body.

What is the biosynthetic pathway of APCDD1 protein? 07/21/2021

The APCDD1 protein is a product of the Apcdd1 gene, and the mRNA encoding the protein is translated by the ribosome to produce the immature protein. The immature APCDD1 protein is processed through a ubiquitin-dependent degradation pathway to form the final mature protein.

What biochemical reactions are involved in the degradation pathway of APCDD1 protein? 05/04/2021

The degradation pathway of APCDD1 protein mainly involves ubiquitination reactions catalyzed by protein ubiquitination enzymes.

Which cells are involved in the signaling pathway of APCDD1 protein? 04/04/2021

APCDD1 protein is mainly associated with epithelial cells and mesenchymal cells.

What is the expression pattern of APCDD1 protein? 03/26/2021

APCDD1 protein expression pattern is tissue-specific, mainly expressed in gastrointestinal tract, breast, lung, liver and heart tissues.

Can the inhibition of APCDD1 protein be used for reference in the treatment of other diseases? 08/23/2020

The inhibitory effect of APCDD1 protein may provide certain reference significance for the treatment of other diseases, such as neuroblastoma.

What is the function and mechanism of APCDD1 protein? 05/14/2020

APCDD1 protein can inhibit the activity of Wnt signaling pathway, thereby affecting cell proliferation, differentiation and apoptosis. Its mechanism is mainly through binding to the Wnt protein, making it inactive, thereby preventing the transmission of Wnt signals.

What diseases is APCDD1 associated with? 09/27/2019

APCDD1 protein is associated with a variety of tumors, such as colon, breast, and esophageal cancer. In addition, APCDD1 protein is also associated with congenital heart disease, diabetes and other diseases.

Can APCDD1 protein be used in clinical diagnosis? 09/06/2019

APCDD1 protein has not yet been found to be useful in clinical diagnosis, but it may be a therapeutic target for some diseases.

What is the relationship between APCDD1 protein and nutrient metabolism? 08/16/2019

APCDD1 protein may be associated with nutrient metabolism, but the specific mechanism remains to be further studied.

What is the role of APCDD1 protein in tumor therapy? 05/18/2019

APCDD1 protein may be involved in tumor cell apoptosis and cell cycle control in tumor therapy, but the specific mechanism of action needs more research.

Customer Reviews (4)

Write a review
Reviews
07/30/2022

    Repeatability of APCDD1 is unmatched, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of repeatability.

    06/06/2022

      The reproducibility of APCDD1 is very good, which can ensure the reliability of the experimental results and facilitate the subsequent research and application.

      06/06/2022

        APCDD1 produced by them has long activity retention time and good experimental effect.

        08/22/2019

          After using APCDD1, the experimental time of Western blot was significantly shortened.

          Ask a Question for All APCDD1 Products

          Required fields are marked with *

          My Review for All APCDD1 Products

          Required fields are marked with *

          0

          Inquiry Basket

          cartIcon
          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends