Recombinant Human APCDD1, Fc-tagged
Cat.No. : | APCDD1-223H |
Product Overview : | A DNA sequence encoding the human APCDD1 (NP_694545.1) (Met1-Gly486) was expressed with the Fc region of human IgG1 at the C-terminus. |
- Specification
- Gene Information
- Related Products
Source : | Human Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from sterile PBS, pH7.4. |
Molecular Mass : | The recombinant human APCDD1/Fc comprises 701 amino acids and has a predicted molecular mass 79.6 kDa. The apparent molecular mass of the protein is approximately 85.7 kDa in SDS-PAGE under reducing conditions. |
Protein length : | Met1-Gly486 |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >85 % as determined by SDS-PAGE |
Stability : | Samples are stable for up to twelve months from date of receipt at -70℃ |
Storage : | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | APCDD1 adenomatosis polyposis coli down-regulated 1 [ Homo sapiens ] |
Official Symbol : | APCDD1 |
Synonyms : | APCDD1; adenomatosis polyposis coli down-regulated 1; protein APCDD1; B7323; hypoptrichosis simplex; adenomatosis polyposis coli down-regulated 1 protein; HHS; HTS; DRAPC1; FP7019; |
Gene ID : | 147495 |
mRNA Refseq : | NM_153000 |
Protein Refseq : | NP_694545 |
MIM : | 607479 |
UniProt ID : | Q8J025 |
Chromosome Location : | 18p11.21 |
Function : | Wnt-protein binding; |
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◆ Lysates | ||
APCDD1-001HCL | Recombinant Human APCDD1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAPCDD1 protein has not been shown to have a direct relationship with pneumonia-tuberculosis.
No clear relationship between APCDD1 protein and immune response has been found.
Studies have shown that the expression level of APCDD1 gene in liver cancer tissues is significantly decreased, and its deletion may be closely related to the occurrence and development of liver cancer.
The role of APCDD1 protein in hepatitis is not yet clear, but it may be related to hepatocyte dysfunction and apoptosis.
The APCDD1 protein is a member of the Wnt inhibitor family and mainly consists of an N-terminal signaling peptide and a C-terminal maturation peptide. The C-terminal peptide chain is mainly composed of multiple interlaced cysteine residues, forming a special domain.
The mechanism of action of APCDD1 protein is independent of the RNA splicing process.
APCDD1 protein may be involved in cardiomyocyte apoptosis, vascular endothelial cell proliferation and other processes in cardiovascular diseases.
The mechanism of action of APCDD1 protein makes it a potential targeted therapeutic molecule, but the relevant clinical studies are currently lacking.
The polymorphism of APCDD1 protein may affect its structure and function, but the exact extent of the impact needs more research.
The APCDD1 protein has not been shown to have a clear relationship with calcium ion regulation in the body.
The APCDD1 protein is a product of the Apcdd1 gene, and the mRNA encoding the protein is translated by the ribosome to produce the immature protein. The immature APCDD1 protein is processed through a ubiquitin-dependent degradation pathway to form the final mature protein.
The degradation pathway of APCDD1 protein mainly involves ubiquitination reactions catalyzed by protein ubiquitination enzymes.
APCDD1 protein is mainly associated with epithelial cells and mesenchymal cells.
APCDD1 protein expression pattern is tissue-specific, mainly expressed in gastrointestinal tract, breast, lung, liver and heart tissues.
The inhibitory effect of APCDD1 protein may provide certain reference significance for the treatment of other diseases, such as neuroblastoma.
APCDD1 protein can inhibit the activity of Wnt signaling pathway, thereby affecting cell proliferation, differentiation and apoptosis. Its mechanism is mainly through binding to the Wnt protein, making it inactive, thereby preventing the transmission of Wnt signals.
APCDD1 protein is associated with a variety of tumors, such as colon, breast, and esophageal cancer. In addition, APCDD1 protein is also associated with congenital heart disease, diabetes and other diseases.
APCDD1 protein has not yet been found to be useful in clinical diagnosis, but it may be a therapeutic target for some diseases.
APCDD1 protein may be associated with nutrient metabolism, but the specific mechanism remains to be further studied.
APCDD1 protein may be involved in tumor cell apoptosis and cell cycle control in tumor therapy, but the specific mechanism of action needs more research.
Customer Reviews (4)
Write a reviewRepeatability of APCDD1 is unmatched, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of repeatability.
The reproducibility of APCDD1 is very good, which can ensure the reliability of the experimental results and facilitate the subsequent research and application.
APCDD1 produced by them has long activity retention time and good experimental effect.
After using APCDD1, the experimental time of Western blot was significantly shortened.
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