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Recombinant Human CLCF1, Fc-tagged

Cat.No. : CLCF1-351H
Product Overview : A DNA sequence encoding the human CLCF1 (NP_037378.1)(Leu28-Phe225) was expressed with the fused Fc region of human IgG1 at the N-terminus.
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  • Gene Information
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Source : Human Cells
Species : Human
Tag : Fc
Form : Lyophilized from sterile PBS, pH7.4.
Molecular Mass : The recombinant human CLCF1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 458 amino acids and has a predicted molecular mass of 50.7 kDa. The apparent molecular mass of the protein is approximately 54 kDa in SDS-PAGE under reducing conditions.
Protein length : Leu28-Phe225
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >85 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : CLCF1 cardiotrophin-like cytokine factor 1 [ Homo sapiens ]
Official Symbol : CLCF1
Synonyms : CLCF1; cardiotrophin-like cytokine factor 1; CRLF1 associated cytokine like factor 1; B cell stimulating factor 3; BSF 3; BSF3; CISS2; CLC; cold induced sweating syndrome 2; NNT 1; NNT1; novel neurotrophin 1; NR6; novel neurotrophin-1; B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; BSF-3; NNT-1;
Gene ID : 23529
mRNA Refseq : NM_001166212
Protein Refseq : NP_001159684
MIM : 607672
UniProt ID : Q9UBD9
Chromosome Location : 11q13.3
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : ciliary neurotrophic factor receptor binding; contributes_to ciliary neurotrophic factor receptor binding; contributes_to cytokine activity; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CLCF1 be measured as a biomarker for certain diseases? 07/22/2021

Research suggests that levels of CLCF1 in blood or tissues may serve as potential biomarkers for specific diseases, aiding in early diagnosis and prognosis.

How is CLCF1 production regulated in the human body? 09/05/2020

The production of CLCF1 is tightly regulated at the transcriptional and post-translational levels, involving various signaling pathways.

Are there any clinical trials exploring the use of CLCF1 in medical interventions? 12/04/2018

Yes, there are ongoing clinical trials investigating the therapeutic potential of CLCF1 in various diseases, including autoimmune disorders and neurodegenerative conditions.

How does CLCF1 interact with other cytokines in the IL-6 family? 08/17/2018

CLCF1 can interact with various receptors and signaling molecules within the IL-6 cytokine family, influencing a range of physiological processes.

In what ways does CLCF1 contribute to neurodegenerative disorders? 10/19/2017

Studies have indicated that CLCF1 may play a role in neurodegenerative conditions, and understanding its function could lead to potential therapies for diseases like Alzheimer's and Parkinson's.

Customer Reviews (3)

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Reviews
10/25/2019

    With their meticulous documentation and support, I am confident that my utilization of CLCF1 protein in clinical trials will meet all necessary regulations and guidelines.

    05/07/2017

      the manufacturer's supply management capabilities assure a seamless and continuous provision of the CLCF1 protein.

      09/19/2016

        In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

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