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Active Recombinant H7N7 NA

Cat.No. : NA-454H
Product Overview : A DNA sequence encoding the Influenza A virus (A/Netherlands/219/2003 (H7N7)) Neuraminidase (Met1-Ser471) was expressed, the cell lysates are collected, and bio-activity was tested.
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Description : Neuraminidase (NA) is a major membrane glycoproteins found on the surface of influenza virus. NA specifically catalyzes the hydrolysis removal of terminal sialic acid residues from viral and cellular glycoconjugates. It is known that HA binds to the sialic acid-containing receptors on the surface of host cells during initial infection, and at the end of an infectious cycle, NA cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. NA thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell. NA is a single-pass type I I membrane protein which exists as a homotetramer, and the transmembrane domain is involved in lipid raft association duringintracellular transport. NA is suggested to play a role in the determination of host range restriction on replication and virulence. Nine subtypes of NA have been identified, and subtypes N1 and N2 have been positively linked to epidemics in man. Influenza A H1N1 virus is a subtype of influenza A virus. Some strains of H1N1 are endemic in humans and cause a small fraction of all influenzalike illness and a small fraction of all seasonal influenza. H1N1 strains caused a few percent of all human flu infections in 2004-2005. Other strains of H1N1 are endemic in pigs (swine influenza) and in birds (avian influenza). H1N1 was the most common cause of human influenza (flu) in 2009. In June 2009, the World Health Organization declared the new strain of swine-origin H1N1 as a pandemic. This strain is often called swine flu by the public media. This novel virus spread worldwide and had caused about 17,000 deaths by the start of 2010.
Source : Human Cells
Species : H7N7
Form : Lyophilized from sterile PBS, pH7.4.
Bio-activity : Measured by its ability to cleave a fluorogenic substrate, 2"-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acidThe specific activity is >100 UThe specific activity is >1000 UOne unit is defined as the amount of enzyme required to cleave 1 nmole of 2
Molecular Mass : The recombinant influenza A H7N7 Neuraminidase comprises 471 amino acids and has a predicted molecular mass of 51.8kDa.
Protein length : Met1-Ser471
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : Hardcopy of COA with reconstitution instruction is sent along with the products.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there NA protein-based therapies in clinical use? 05/01/2023

Yes, some RNA-based therapies target specific NA proteins for conditions like spinal muscular atrophy.

How do histones relate to epigenetic modifications and clinical outcomes? 08/07/2019

Changes in histone modifications can influence gene expression and contribute to various diseases.

How are NA proteins used in cancer research and treatment? 03/20/2019

NA proteins are studied to understand oncogenesis, and some drugs target NA protein interactions to treat cancer.

Can NA proteins be used for gene therapy? 07/18/2018

NA proteins can be involved in gene therapy strategies to manipulate gene expression for therapeutic purposes.

How are NA proteins involved in the regulation of cell cycle and cancer progression? 12/05/2016

NA proteins control the cell cycle, and dysregulation can contribute to uncontrolled cell growth seen in cancer.

Customer Reviews (3)

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Reviews
11/26/2020

    I highly recommend the NA protein for a variety of experimental applications.

    09/08/2019

      I enthusiastically recommend the NA protein to fellow researchers who seek an unparalleled product accompanied by dedicated customer assistance.

      11/16/2018

        the NA protein stands out for its exceptional quality, coupled with the outstanding technical support delivered by the manufacturer.

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