Recombinant Human SIK, GST-tagged
Cat.No. : | SIK1-48H |
Product Overview : | Recombinant human SIK (1-303) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
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Description : | SIK is a protein kinase that is involved in regulating AMPK-related kinases. SIK may mediate the physiological effects of LKB1, including its tumour suppressor function. SIK is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~61 kDa |
Applications : | Kinase Assay, Western Blot |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | SIK1 salt-inducible kinase 1 [ Homo sapiens ] |
Official Symbol : | SIK1 |
Synonyms : | SIK1; salt-inducible kinase 1; SNF1 like kinase , SNF1LK; serine/threonine-protein kinase SIK1; msk; myocardial SNF1 like kinase; SIK-1; SNF1-like kinase; myocardial SNF1-like kinase; salt-inducible protein kinase 1; serine/threonine protein kinase; serine/threonine-protein kinase SNF1LK; serine/threonine-protein kinase SNF1-like kinase 1; MSK; SIK; SNF1LK; |
Gene ID : | 150094 |
mRNA Refseq : | NM_173354 |
Protein Refseq : | NP_775490 |
MIM : | 605705 |
UniProt ID : | P57059 |
Chromosome Location : | 21q22.3 |
Pathway : | LKB1 signaling events, organism-specific biosystem; |
Function : | 14-3-3 protein binding; ATP binding; ATP binding; cAMP response element binding protein binding; magnesium ion binding; magnesium ion binding; nucleotide binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
SIK1-8172M | Recombinant Mouse SIK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SIK1-5061R | Recombinant Rat SIK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SIK1-432H | Recombinant Human SIK1 protein, His-tagged | +Inquiry |
SIK1-6248C | Recombinant Chicken SIK1 | +Inquiry |
SIK1-15134M | Recombinant Mouse SIK1 Protein | +Inquiry |
◆ Lysates | ||
SIK1-1842HCL | Recombinant Human SIK1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1624 | SIK1 Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulation of SIK1 has been implicated in cancer. It can influence cell proliferation and survival by affecting the activity of transcription factors involved in cell cycle control and apoptosis.
SIK1 plays a role in adipose tissue metabolism by modulating the activity of transcription factors involved in lipogenesis and lipolysis. Dysregulation may contribute to metabolic disorders like obesity and insulin resistance.
SIK1, or Salt-Inducible Kinase 1, is involved in the regulation of cellular responses to various stimuli, including stress, metabolism, and inflammation.
SIK1 regulates energy homeostasis by phosphorylating and modulating the activity of key metabolic regulators, such as cAMP response element-binding protein (CREB) and class IIa histone deacetylases.
SIK1 is activated in response to environmental stressors, such as osmotic stress. It regulates stress signaling pathways through the phosphorylation of downstream effectors, modulating cellular stress responses.
Customer Reviews (3)
Write a reviewOur lab swears by this product! It's a versatile and reliable tool for our experiments.
The quality control is evident in the data precision we achieve.
As a researcher, I can't live without this product. Makes my experiments more accurate and efficient.
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