Recombinant Human ITGAM, GST-tagged
Cat.No. : | ITGAM-231H |
Product Overview : | Recombinant Human ITGAM(111 a.a. - 220 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ. |
- Specification
- Gene Information
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Description : | This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 37.84 kDa |
AA Sequence : | QTCSENTYVKGLCFLFGSNLRQQPQ KFPEALRGCPQEDSDIAFLIDGSGS IIPHDFRRMKEFVSTVMEQLKKSKT LFSLMQYSEEFRIHFTFKEFQNNPN PRSLVKPITQ |
Applications : | ELISA; WB-Re; AP; Array |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) [ Homo sapiens (human) ] |
Official Symbol : | ITGAM |
Synonyms : | ITGAM; CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; integrin, alpha M (complement component 3 receptor 3 subunit); integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit |
Gene ID : | 3684 |
mRNA Refseq : | NM_000632 |
Protein Refseq : | NP_000623 |
MIM : | 120980 |
UniProt ID : | P11215 |
Chromosome Location : | 16p11.2 |
Pathway : | Cell adhesion molecules (CAMs); Focal Adhesion; IL-5 Signaling Pathway |
Function : | glycoprotein binding; heparan sulfate proteoglycan binding; heparin binding |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt facilitates leukocyte adhesion to blood vessel walls and migration to sites of inflammation or infection.
Targeting ITGAM could provide new treatments for autoimmune and inflammatory diseases by modulating immune cell activity.
Genetic mutations in ITGAM can lead to altered immune functioning, increasing the risk of autoimmune diseases.
ITGAM plays a key role in the immune system's ability to combat infections and clear pathogens.
ITGAM works in concert with other immune system components to orchestrate a coordinated response to threats.
ITGAM, integral to leukocyte function, is crucial for mediating immune cell adhesion and phagocytosis.
Altered ITGAM activity can exacerbate or diminish inflammatory responses, affecting disease progression.
Customer Reviews (3)
Write a reviewReliable data for credibility. Trusted for results.
Timely and precise results. Accelerates our research timelines.
Efficient and dependable service. Enhances research quality.
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