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Recombinant Human ITGAM, GST-tagged

Cat.No. : ITGAM-231H
Product Overview : Recombinant Human ITGAM(111 a.a. - 220 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.
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  • Gene Information
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Description : This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 37.84 kDa
AA Sequence : QTCSENTYVKGLCFLFGSNLRQQPQ KFPEALRGCPQEDSDIAFLIDGSGS IIPHDFRRMKEFVSTVMEQLKKSKT LFSLMQYSEEFRIHFTFKEFQNNPN PRSLVKPITQ
Applications : ELISA; WB-Re; AP; Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) [ Homo sapiens (human) ]
Official Symbol : ITGAM
Synonyms : ITGAM; CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; integrin, alpha M (complement component 3 receptor 3 subunit); integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit
Gene ID : 3684
mRNA Refseq : NM_000632
Protein Refseq : NP_000623
MIM : 120980
UniProt ID : P11215
Chromosome Location : 16p11.2
Pathway : Cell adhesion molecules (CAMs); Focal Adhesion; IL-5 Signaling Pathway
Function : glycoprotein binding; heparan sulfate proteoglycan binding; heparin binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does ITGAM contribute to the adhesion and migration of leukocytes? 02/11/2022

It facilitates leukocyte adhesion to blood vessel walls and migration to sites of inflammation or infection.

What potential therapeutic applications arise from targeting ITGAM in immune-related disorders? 04/14/2020

Targeting ITGAM could provide new treatments for autoimmune and inflammatory diseases by modulating immune cell activity.

How do genetic variations in ITGAM affect immune responses and susceptibility to autoimmune diseases? 03/01/2020

Genetic mutations in ITGAM can lead to altered immune functioning, increasing the risk of autoimmune diseases.

What role does ITGAM play in the immune system's response to infection? 11/02/2019

ITGAM plays a key role in the immune system's ability to combat infections and clear pathogens.

How does ITGAM interact with other components of the immune system? 12/21/2018

ITGAM works in concert with other immune system components to orchestrate a coordinated response to threats.

What is the primary role of ITGAM in immune cell function? 04/08/2018

ITGAM, integral to leukocyte function, is crucial for mediating immune cell adhesion and phagocytosis.

What is the impact of altered ITGAM activity on inflammatory processes? 04/04/2017

Altered ITGAM activity can exacerbate or diminish inflammatory responses, affecting disease progression.

Customer Reviews (3)

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Reviews
12/10/2022

    Reliable data for credibility. Trusted for results.

    02/27/2022

      Timely and precise results. Accelerates our research timelines.

      06/27/2018

        Efficient and dependable service. Enhances research quality.

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