Native Human fetal cord serum
Cat.No. : | AFP-3017H |
Product Overview : | a-fetoprotein (AFP) |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] |
Source : | Human fetal cord serum |
Species : | Human |
Form : | Lyophilised powder from 0.1 M PBS, pH 7.4 - 7.6 |
Molecular Mass : | 68,678 Da |
Protein length : | 609 |
Purity : | Purity >98 % (SDS-PAGE) |
Applications : | Immunoassay |
Notes : | Small volumes of AFP protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | AFP alpha-fetoprotein [ Homo sapiens ] |
Official Symbol : | AFP |
Synonyms : | AFP; alpha-fetoprotein; HPAFP; FETA; alpha-fetoglobulin; alpha-1-fetoprotein; |
Gene ID : | 174 |
mRNA Refseq : | NM_001134 |
Protein Refseq : | NP_001125 |
UniProt ID : | P02771 |
Chromosome Location : | 4q11-q13 |
Pathway : | Direct p53 effectors, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; |
Function : | metal ion binding; |
Products Types
◆ Recombinant Protein | ||
AFP-289H | Recombinant Human AFP Protein, His (Fc)-Avi-tagged | +Inquiry |
AFP-1059H | Recombinant Human AFP Protein (Met1-Val609), HlgG1 Fc-tagged | +Inquiry |
AFP-082H | Recombinant Human AFP Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
AFP-0004H | Recombinant Human AFP Protein | +Inquiry |
AFP-52H | Recombinant Human AFP Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
AFP-412H | Native Human AFP Protein | +Inquiry |
AFP-1180H | Native Human Alpha-Fetoprotein | +Inquiry |
AFP-3018P | Native pig AFP | +Inquiry |
◆ Lysates | ||
AFP-1706HCL | Recombinant Human AFP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionThe clinical utility of AFP protein as a diagnostic or prognostic marker can be validated through clinical studies using patient samples, correlation analyses with disease outcomes, or comparison with existing diagnostic methods.
Downstream signaling pathways or cellular responses triggered by AFP protein binding or activation can be studied using techniques such as Western blotting, gene expression analysis, or functional assays specific to the signaling pathways of interest.
Therapeutic interventions or treatment strategies targeting AFP protein can be evaluated for efficacy and safety using in vitro or in vivo models, disease-specific assays, or clinical trials to assess their impact on disease progression, patient outcomes, or potential side effects.
The cellular and molecular mechanisms underlying the production and secretion of AFP protein can be elucidated through techniques such as gene expression analysis, protein trafficking studies, or immunofluorescence microscopy.
Genetic variations or mutations in the AFP gene that impact its expression or function can be investigated through genetic association studies, functional characterization of mutant variants, or population-based analyses.
The regulatory factors or signaling pathways that control the expression and transcriptional regulation of the AFP gene can be studied using techniques such as promoter analysis, transcription factor binding assays, or gene knockout/knockdown approaches.
The functional roles of AFP protein in embryonic development, tissue regeneration, or disease progression can be investigated through genetic or pharmacological perturbations, in vitro or in vivo model systems, or functional assays specific to the biological processes of interest.
Specific biomarkers or imaging techniques for detecting AFP protein in biological samples can be developed and their sensitivity and specificity can be assessed using techniques such as ELISA, immunohistochemistry, or imaging modalities like MRI or PET.
The interactions of AFP protein with its binding partners or ligands can be studied using techniques such as co-immunoprecipitation, surface plasmon resonance, or receptor-binding assays.
The immune-related functions of AFP protein, such as immunomodulation or immune evasion, can be investigated using techniques like immune cell assays, cytokine profiling, or immune response assays.
Customer Reviews (3)
Write a reviewInvestigating protein-protein interactions in cellular stress responses for cell survival.
Dissecting protein-protein interactions in viral replication for antiviral strategies.
Mapping protein-protein interactions in protein degradation pathways for proteostasis.
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